Results 61 to 70 of about 783,646 (327)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Geochemical Discrimination of Monazite Source Rock Based on Machine Learning Techniques and Multinomial Logistic Regression Analysis

Geosciences, 2020
Detrital monazite geochronology has been used in provenance studies. However, there are complexities in the interpretation of age spectra due to their wide occurrence in both igneous and metamorphic rocks. We use the multinomial logistic regression (MLR)
Keita Itano, Kenta Ueki, Tsuyoshi Iizuka, Tatsu Kuwatani   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Predictors of Source Memory Success and Failure in Older Adults

Frontiers in Aging Neuroscience, 2019
Source memory decline has been identified as one of the types of memory most seriously affected during older age. It refers to our capacity to recollect the contextual information in which our experiences take place.
Selene Cansino, Frine Torres-Trejo, Cinthya Estrada-Manilla, Liuba Ramírez-Barajas, Miguel Pérez-Loyda, Aidé Nava-Chaparro, Mariana Hernández-Ladrón-deGuevara, Silvia Ruiz-Velasco   +7 more
doaj   +1 more source

Global existence of solutions to Keller-Segel chemotaxis system with heterogeneous logistic source and nonlinear secretion [PDF]

, 2021
A Gurusamy, Asha K. Dond, André H. Erhardt   +2 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Parameter estimation of Stochastic Logistic Model : Levenberg-Marquardt Method [PDF]

, 2009
In this paper, we estimate the drift and diffusion parameters of the stochas- tic logisticmodels for the growth of Clostridium Acetobutylicum P262 using Levenberg- Marquardt optimization method of non linear least squares.
Abd. Rahman, Haliza, Bahar, Arifah, Mohd. Aziz, Mohd. Khairul Bazli, Rosli, Norhayati, Salleh, Madihah, Weber, Gerhard-Wilhelm   +5 more
core  

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Global existence and boundedness in a fully parabolic attraction-repulsion chemotaxis system with signal-dependent sensitivities without logistic source [PDF]

, 2021
Yutaro Chiyo, Masaaki Mizukami, Tomomi Yokota   +2 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source