Results 171 to 180 of about 129,509 (273)

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Advanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang   +10 more
wiley   +1 more source

Assessing the deployment of solar-driven hydrogen from biomass at scale in the U.S. [PDF]

Sci Rep
Iloeje CO, Runchey S, Gallier A, Oke D, Yu L, Xavier AS.   +5 more
europepmc   +1 more source

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

Mobility in Logistics

, 2019
openaire   +1 more source

White Shark Optimization for Solving Workshop Layout Optimization Problem. [PDF]

Biomimetics (Basel)
Guo B, Wei Y, Luo Q, Zhou Y.
europepmc   +1 more source

Proteomics‐Empowered Microfluidic‐SERS Immunoassay for Identifying and Detecting Biomarkers of Micropapillary Lung Adenocarcinoma

Advanced Science, EarlyView.
The presence of a micropapillary (MPP) component is critical for lung adenocarcinoma (LUAD) surgery, yet reliable blood biomarkers remain lacking. This study integrates proteomics for biomarker identification, a nanomixing‐enhanced surface‐enhanced Raman spectroscopy (SERS) platform for sensitive detection, and machine learning for accurate ...
Dechun Zhang, Kaiming Peng, Hui Xu, Yanping Chen, Jing Wang   +4 more
wiley   +1 more source

Investigation of green supply chain management practices and sustainability in Indian manufacturing enterprises using a structural equation modelling approach. [PDF]

Sci Rep
Gupta P, Sharma Y, Chauhan A, Parewa B, Rai P, Naik N.   +5 more
europepmc   +1 more source

A Dual‐Modal Wearable Pulse Detection System Integrated with Deep Learning for High‐Accuracy and Low‐Power Sleep Apnea Monitoring

Advanced Science, EarlyView.
A dual‐modal wearable pulse detection system is developed for sleep apnea monitoring by integrating a self‐powered PENG and PPG sensor with a biomimetic fingertip structure. Through a two‐stage detection strategy, continuous PPW monitoring and on‐demand PPG detection achieve high‐accuracy sleep apnea recognition while maintaining low power consumption.
Jia Wang, Jiangtao Xue, Yang Zou, Yuxin Ma, Junhan Xu, Yanming Li, Fei Deng, Yiqian Wang, Kai Xing, Zhou Li, Tong Zou   +10 more
wiley   +1 more source

Effects of Different Litchi E-Commerce Logistics Packaging Methods on Microenvironment and Fruit Quality Variations. [PDF]

Foods
Guo J, Liu D, Lin G, Qiu H, Guo P, Ding Z, Wu D, Wang J, Lv E.   +8 more
europepmc   +1 more source

Gradient Nanostructures and Machine Learning Synergy for Robust Quantitative Surface‐Enhanced Raman Scattering

Advanced Science, EarlyView.
A novel SERS platform using gradient nanostructures and machine learning is presented. Gradient nanostructures minimize fabrication variability and enhance spectral diversity. The ML model significantly improves quantification precision, robustness and reproducibility, reducing test MSE by 84.8% and increasing R2 by 61.2%, enabling reliable real‐world ...
Xiaoyu Zhao, Yuxia Wang, Yuting Liu, Xinyi Chen, Mingyu Cheng, Yaxin Wang, Jiahong Wen, Renxian Gao, Kun Zhang, Fengyi Zhang, Rufei Cui, Yongjun Zhang, Zengyao Wang, Bin Ai   +13 more
wiley   +1 more source