Results 261 to 270 of about 1,009,662 (363)

Dual‐Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures

open access: yesAdvanced Science, EarlyView.
A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng   +13 more
wiley   +1 more source

Logistics and Technique for Procurement of Intestinal, Pancreatic, and Hepatic Grafts From the Same Donor

open access: green, 2000
K Abu-Elmagd   +10 more
openalex   +2 more sources

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

open access: yesAdvanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao   +14 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao   +8 more
wiley   +1 more source

Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model

open access: yesAdvanced Science, EarlyView.
This study examines how the human hippocampus encodes visual memory categories. By decoding spiking activity from CA3 and CA1 neurons using an interpretable model, it reveals that category‐specific representations emerge from distributed temporal coding.
Xiwei She   +17 more
wiley   +1 more source

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

open access: yesAdvanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu   +10 more
wiley   +1 more source

In Situ Redox Manipulation Proof-of-Principle Test at the Fort Lewis Logistics Center: Final Report

open access: bronze, 2000
Vincent R. Vermeul   +5 more
openalex   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

open access: yesAdvanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu   +5 more
wiley   +1 more source

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