Results 291 to 300 of about 935,138 (343)

Feasibility of Physical Therapy Evaluation Symptom Provocation Tests in Older Adults With Mild Traumatic Brain Injury: Mixed Methods Study. [PDF]

JMIR Form Res
Barrett CA, Goetting MG, Danna-Dos-Santos A.   +2 more
europepmc   +1 more source

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

Generative AI and Blockchain-Integrated Multi-Agent Framework for Resilient and Sustainable Fruit Cold-Chain Logistics. [PDF]

Foods
Khanna A, Jain S, Sah A, Dangi S, Sharma A, Tiang SS, Wong CH, Lim WH.   +7 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Analyzing the coupling coordination between aviation logistics and the regional economy: Identifying coupling mechanisms and critical influencing factors. [PDF]

PLoS One
Liang L, Chen P, Zhang M.
europepmc   +1 more source

Utilizing Causal Network Markers to Identify Tipping Points ahead of Critical Transition

Advanced Science, EarlyView.
The study proposes a causal network markers (CNMs) framework to identify early‐warning signals preceding critical transitions. It validates CNMs on various computational benchmark models and real‐world datasets, demonstrating higher accuracy and flexibility compared to existing approaches.
Shirui Bian, Zezhou Wang, Siyang Leng, Wei Lin, Jifan Shi   +4 more
wiley   +1 more source

Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report. [PDF]

Respir Med Case Rep
Zhang K, Wang Y, Li Y.
europepmc   +1 more source

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility

Advanced Science, EarlyView.
RAD21L1 is upregulated in human Sertoli cells to be transited to become spermatogonial stem cells by overexpressing DAZ family three genes. RAD21L1 is sufficient and effective for reprogramming Sertoli cells into human spermatogonial stem cells with high safety through DNA methylation.
Caimei He, Yinghong Cui, Wei Chen, Chunyun Li, Zuping He   +4 more
wiley   +1 more source

Rare complete replacement-type left hepatic artery originating from the left gastric artery: A case report. [PDF]

World J Hepatol
Gao XX, Xu XX, Chen P, He TX, Du CZ, Zhou Q, Zhou GF, Guo XW, Peng JR, Li HT.   +9 more
europepmc   +1 more source