Results 61 to 70 of about 427,976 (346)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Digital Twins Driven Supply Chain Visibility within Logistics: A New Paradigm for Future Logistics

Applied System Innovation, 2021
The supply chains shaping their distribution networks become more diverse as companies respond to global markets’ stringent criteria. This is also counterproductive to the visibility of the supply chain within the company and can adversely affect the ...
T. Moshood, G. Nawanir, S. Sorooshian, O. Okfalisa   +3 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Noise-Based Frequency Spectrum Correction Method Using Interior Point Approach

IEEE Access
The spectral correction of noisy real sinusoidal signals is of critical importance; however, the presence of spectral leakage and noise introduces significant challenges.
Guichun Yang, Shengyou Zhou, Han Chen, Huiyue Yang, Weixing Hua, Zhaojie Wu, Yan Chen   +6 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Proposals for improving the Logistics Performance Index

Asian Journal of Shipping and Logistics, 2020
The purpose of this study is to propose ways for improving the current Logistics Performance Index published by the World Bank. The Logistics Performance Index is based on a global survey of logistics experts, which can be biased towards a subjective ...
Ruslan Beysenbaev, Yuri Dus
doaj   +1 more source

Food Logistics 4.0: Opportunities and Challenges

Logistics, 2020
Food Logistics 4.0 is a term derived from Industry 4.0 focusing on all the aspects of food logistics management based on cyber-physical systems.
Sandeep Jagtap, Farah Bader, G. Garcia-Garcia, H. Trollman, T. Fadiji, K. Salonitis   +5 more
semanticscholar   +1 more source

Logistics and exports [PDF]

, 2008
Drawing on a new and comprehensive measure of logistics quality, our gravity model suggests logistics in the exporting and partner-country can have an important impact on bilateral exports. A one standard deviation improvement in the exporter’s logistics quality, which for example would improve Gabon to the level of Guinea, would raise exports by ...
Alberto Behar, Phil Manners
openaire   +3 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Measurement of Logistics Radiation Range and Improvement of Logistics Radiation Ability of City Clusters

Discrete Dynamics in Nature and Society, 2022
The current development plans for logistics of city clusters often pursue investment speed, while overlooking the economic benefits of logistics within city clusters.
Qiaoping Zhou, Rui Wang, Ki-Hyung Bae, Xuejiao Wang   +3 more
doaj   +1 more source