Results 221 to 230 of about 8,794,145 (298)
Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Advanced Science, EarlyView.DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li +17 more
wiley +1 more source
Smart Logistics Model for Supply Chain Management via Brain-Inspired Geometric Deep Networks. [PDF]
Biomimetics (Basel)Khaleghi M +5 more
europepmc +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
The effect of the China-Thailand railway on Thailand's trade with China Guangxi Province. [PDF]
PLoS OneWei S, Xia L.
europepmc +1 more source
Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
A Digital Twin-Driven Sensing and Fuzzy Decision Framework for Safety Monitoring of Autonomous Mobile Robot Systems in Intralogistics. [PDF]
Sensors (Basel)Werbińska-Wojciechowska S +2 more
europepmc +1 more source
Advanced Science, EarlyView.An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li +15 more
wiley +1 more source
Enablers and barriers to implementing a digital logistics system: A qualitative evaluation of OpenLMIS for Nigeria's vaccine supply chain. [PDF]
PLOS Glob Public HealthNoiki IA +6 more
europepmc +1 more source
MXene‐Based Room‐Temperature NO2 Gas Sensors: A Meta‐Analysis
Advanced Science, EarlyView.This study presents the first comprehensive meta‐analysis of MXene‐based NO2 sensors, decoding 32 study characteristics across 61 peer‐reviewed studies. By isolating materials chemistry as the primary performance driver over device‐level parameters, the authors establish a methodological blueprint and a predictive structure–function map to accelerate ...
Alexander Khort +3 more
wiley +1 more source