Results 241 to 250 of about 8,249,296 (337)

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

Advanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen, Xiaoni Gao, Shuai Lu, Yi Zhang, Xing Zheng, Matthaios Santamouris   +5 more
wiley   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Broadband Achromatic Programmable Electromagnetic Camouflage via Fluidic‐Accessible Metasurface

Advanced Science, EarlyView.
A fluidic access metasurface enables dynamic, broadband electromagnetic illusions. By physically reconstructing conductive patterns with liquid metal, the metasurface achieves real‐time, pixel‐level control over phase dispersion. This allows for the programmable generation of arbitrary strong scattering point arrays, effectively deceiving high ...
Shipeng Liu, Jiahao Zhang, Jiale Wang, Zeyao Chen, Zhaotong Yu, Jinhong Luo, Jiabao Luo, Rujia Cao, Shuxi Gong, Qingxin Guo, Ping Li, Rujiang Li, Ke Chen, Yongtao Jia, Ying Liu   +14 more
wiley   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Operationalizing preventive care: the preventive health logistics ecosystem framework for aging societies. [PDF]

Front Public Health
Tan HY, Loo ES, Foo C, Tay HL, Teo KW, Low LL.   +5 more
europepmc   +1 more source

The logistics of information management [PDF]

, 2002
Sharif, AM
core  

Towards Climate Neutrality by 2050: Role of Aluminum for Short‐ and Long‐Term Energy and Hydrogen Storage

Advanced Energy Materials, EarlyView.
The Aluminum energy storage cycle involves the use of renewable energy for Al production and the generation of heat (dry cycle) and heat and H2 (wet cycle) for energy production via Al‐steam combustion. ABSTRACT Reaching climate neutrality by 2050 requires innovative long‐term energy storage (LTES) solutions beyond the current use of fossil fuels ...
Lorenzo Trombetti, Stefano Passerini, Linda Barelli   +2 more
wiley   +1 more source

Cross-border logistics risk warning system based on federated learning. [PDF]

Sci Rep
Liang X.
europepmc   +1 more source