Results 201 to 210 of about 9,077,676 (255)
Advanced Science, EarlyView.By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo +15 more
wiley +1 more source
Advanced Science, EarlyView.Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin +6 more
wiley +1 more source
Advanced Science, EarlyView.Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou +13 more
wiley +1 more source
Climate Change is Rewriting the Hydroclimatic Operating Envelope of Mines
Advanced Science, EarlyView.Climate change is shown to shift the hydroclimatic operating envelope of mines: 16.2% of represented mine locations have already changed Köppen subtype, rising to 42.5% by late century under SSP5‐8.5. Divergent water trajectories are filtered through geology, infrastructure and lifecycle stage, indicating that adaptation requires monitored, scenario ...
Haoxuan Yu +3 more
wiley +1 more source
Advanced Science, EarlyView.Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.Primer‐programmed amplicon encoding enables reporter‐probe‐free multiplex nucleic acid identification using glass nanopore sensing and deep neural network decoding. ABSTRACT Single‐reaction multiplex nucleic acid testing (NATs) must both co‐amplify multiple targets and distinguish the resulting amplicons within the product mixture.
Md. Ahasan Ahamed +4 more
wiley +1 more source
From Artificial to Embodied and Physical Intelligence in Smart Manufacturing
Advanced Science, EarlyView.Smart manufacturing is reframed through complementary artificial, embodied, and physical intelligence, spanning computational reasoning, perception‐action coupling, and material‐level adaptation. Their integration across design, fabrication, operation, and maintenance reveals how intelligence can be co‐designed across algorithms, embodied agents, and ...
Kang Wang +9 more
wiley +1 more source
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
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2023
Management students will find Logistics Management to be an all-inclusive textbook that covers all the bases. Having an efficient logistic network allows businesses to compete on a global and local scale. This student-friendly book lays out the theory in great detail and includes a plethora of figures and exhibits that highlight the managerial ...
Kiran S. Kale, Sandeep Suresh Londhe
+6 more sources
Management students will find Logistics Management to be an all-inclusive textbook that covers all the bases. Having an efficient logistic network allows businesses to compete on a global and local scale. This student-friendly book lays out the theory in great detail and includes a plethora of figures and exhibits that highlight the managerial ...
Kiran S. Kale, Sandeep Suresh Londhe
+6 more sources
2021
The textbook consistently examines the process of administration of the logistics system of the enterprise, consisting of performing basic, technological and socio-psychological management functions, ensuring decision-making in the organization and improvement of material, information and other related flows in the enterprise, as well as achieving long-
Grigoriy Levkin, Natal'ya Kurshakova
openaire +2 more sources
The textbook consistently examines the process of administration of the logistics system of the enterprise, consisting of performing basic, technological and socio-psychological management functions, ensuring decision-making in the organization and improvement of material, information and other related flows in the enterprise, as well as achieving long-
Grigoriy Levkin, Natal'ya Kurshakova
openaire +2 more sources