Results 61 to 70 of about 20,198 (255)

Population pharmacokinetics and pharmacodynamics of canagliflozin in paediatric patients with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts, Per Olsson Gisleskog, Martine Neyens, Juan José Perez Ruixo, Saberi Rana Ali, Iolanda Cirillo, Oliver Ackaert   +6 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Analyzing zero‐truncated recurrent event data by stratified regression with time‐varying coefficients

Canadian Journal of Statistics, EarlyView.
Abstract This article presents a strategy for conducting regression analysis of zero‐truncated recurrent event data. The research is partly motivated by a pediatric mental health care (PMHC) program based on administrative data. We are particularly interested in how the occurrence of an event depends on its past occurrences and the associated ...
Anqi A. Chen, X. Joan Hu, Rhonda J. Rosychuk, Leilei Zeng   +3 more
wiley   +1 more source

Preconfigured, Skewed Distribution of Firing Rates in the Hippocampus and Entorhinal Cortex

Cell Reports, 2013
Despite the importance of the discharge frequency in neuronal communication, little is known about the firing-rate patterns of cortical populations. Using large-scale recordings from multiple layers of the entorhinal-hippocampal loop, we found that the ...
Kenji Mizuseki, György Buzsáki
doaj   +1 more source

Lognormal and Pareto distributions in the Internet [PDF]

Computer Communications, 2005
Numerous studies have reported long-tailed distributions for various network metrics, including file sizes, transfer times, and burst lengths. We review techniques for identifying long-tailed distributions based on a sample, propose a new technique, and apply these methods to datasets used in previous reports.
openaire   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses to Support Cofetuzumab Pelidotin (ABBV‐647) Dose Optimization in Non‐Small Cell Lung Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf, Melanie Rinas, Benjamin Engelhardt, Rabih Saab, Cen Guo, Cristiano Ferlini, Kevin J. Freise, Rajeev M. Menon, Akshanth R. Polepally   +8 more
wiley   +1 more source

On the Shifted Hybrid Log-Normal Distribution

Statistica
The log-normal distribution is widely used to model positive valued data in many areas of applied research. However, sometimes the log-normal distribution does not completely satisfy the fitting expectations in every real life situations.
Damodaran Santhamani Shibu, Soman Latha Nitin, Muhammed Rasheed Irshad   +2 more
doaj   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Probabilistic prediction of rate‐dependent rock strength using natural gradient boosting and Gaussian process regression

Deep Underground Science and Engineering, EarlyView.
Probabilistic natural gradient boosting and Gaussian process regression models accurately predict rate‐dependent rock strength across lithologies. Static strength and strain rate dominate, while geometric factors have minimal influence, enabling interpretable and uncertainty‐aware predictions for dynamic geomechanical applications. Abstract The dynamic
Hadi Fathipour‐Azar
wiley   +1 more source

Nanocubes and Cuboctahedra: Entropic Stabilization Versus Thermal Segregation in Rock Salt‐ and Spinel‐Type Multinary Oxides from Spray‐Flame Synthesis

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Spray‐flame synthesis enables highly flexible and scalable production of multinary and high‐entropy oxide nanoparticles due to high synthesis temperatures with subsequent quenching. Temperature‐dependent in situ diffraction of as‐synthesized materials clearly reveals entropy stabilization in rock salt lattices, while spinels—featuring tetrahedral and ...
Mohammed‐Ali Sheikh, Steven Angel, Sabrina Schleich, Leon Müller, Jan Ternieden, Hatem M. A. Amin, Christof Schulz, Hartmut Wiggers   +7 more
wiley   +1 more source