Results 211 to 220 of about 4,474,743 (294)

Population pharmacokinetics and pharmacodynamics of canagliflozin in paediatric patients with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3622-3633, October 2026.
Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts, Per Olsson Gisleskog, Martine Neyens, Juan José Perez Ruixo, Saberi Rana Ali, Iolanda Cirillo, Oliver Ackaert   +6 more
wiley   +1 more source

Statistics of multiscale fragmentation in the Primorsky fault zone. [PDF]

Sci Rep
Ostapchuk A, Chinkin V, Grigorieva A, Pavlov D.   +3 more
europepmc   +1 more source

Species Extinction Curves Under Emergent Spatiotemporal Land‐Use Processes and the Role of Protected Areas

Ecology and Evolution, Volume 16, Issue 10, October 2026.
Dynamic land‐use change reshapes extinction risk by altering where and how converted areas emerge, expand, and merge. Our spatially explicit framework integrates these land‐use dynamics with species geographic ranges and protected‐area implementation. Frequent emergence of spatially dispersed land‐use patches shifts species loss toward later stages of ...
Nao Takashina, Buntarou Kusumoto
wiley   +1 more source

Statistical Uncertainty of Inhalation Dose Coefficients in Consequence Management: Propagated Dose Uncertainty in ICRP 66 Human Respiratory Tract Model. [PDF]

Health Phys
Mate-Kole EM, Graffigna M, Margot D, Cochran LD, Jelsema C, Buchbinder Shadur L, Kalinowski A, Dewji SA.   +7 more
europepmc   +1 more source

From a Probabilistic PBEE Framework to Risk‐Targeted Structural Design With Cascading Hazards: Engineering Application for Seismic–Radiological Safety

Earthquake Engineering &Structural Dynamics, Volume 55, Issue 12, Page 3098-3114, 10 October 2026.
ABSTRACT Earthquake‐induced damage of structures can trigger cascading hazards, linking structural performance to nonstructural consequences. In current engineering practice, these two aspects are typically addressed separately, limiting the ability to account for such coupled effects in design.
Matjaž Dolšek, Peter Fajfar, Anže Babič   +2 more
wiley   +1 more source

Analysis of Risk Factors Affecting Epilepsy Seizure Frequency with Statistical Models. [PDF]

Sisli Etfal Hastan Tip Bul
Cetin S, Onur GY, Topbas E, Sanver SD.
europepmc   +1 more source

Analytical Framework for System‐Level Fragility Surfaces of Reinforced Concrete Bridges Under Mainshock‐Aftershock Sequences

Earthquake Engineering &Structural Dynamics, Volume 55, Issue 13, Page 3264-3284, 25 October 2026.
ABSTRACT Conventional single intensity measure (IM) fragility approaches with simplified component dependency assumptions overlook the progressive damage accumulation and evolving inter‐component correlations that govern system behavior under mainshock‐aftershock (MSAS) loading.
Muhammad Rashid, Mayuko Nishio
wiley   +1 more source

Delay-Modulated Nonlinear Stochastic Mode Veering in Inertially Coupled Vibration Systems. [PDF]

Entropy (Basel)
Zhang L, Han Z, Wang Q.
europepmc   +1 more source

Surrogate‐Based Time‐Continuous Seismic Fragility Assessment of Corrosion‐Deteriorated Reinforced Concrete Bridges Under Climate Change

Earthquake Engineering &Structural Dynamics, Volume 55, Issue 13, Page 3338-3362, 25 October 2026.
ABSTRACT Seismic fragility assessment of reinforced concrete (RC) bridges exposed to corrosive environments must reliably capture time‐dependent deterioration impacts. Climate change compounds this challenge through nonstationary temperature and humidity variations that accelerate bridge corrosion.
Yexiang Yan, Yazhou Xie
wiley   +1 more source

Statistical Uncertainty of Inhalation Dose Coefficients: Impact of Particle Deposition in ICRP 66 Human Respiratory Tract Model. [PDF]

Health Phys
Margot D, Mate-Kole EM, Cochran LD, Jelsema C, Graffigna M, Buchbinder Shadur L, Kalinowski A, Dewji SA.   +7 more
europepmc   +1 more source