Results 51 to 60 of about 27,531 (299)

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Modelando la distribución del número de co-autores por artículo Modeling the distribution of co-authorships by paper

Investigación Bibliotecológica: Archivonomía, Bibliotecología e Información, 2011
Este artículo explora la modelación del número de autores que colaboran en la publicación de un artículo. Con ese fin se analizaron la distribución geométrica, la distribución Poisson truncada, la distribución Poisson lognormal y la distribución Gauss ...
Rubén Urbizagástegui Alvarado, Cristina Restrepo Arango   +1 more
doaj  

Population pharmacokinetics and pharmacodynamics of canagliflozin in paediatric patients with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts, Per Olsson Gisleskog, Martine Neyens, Juan José Perez Ruixo, Saberi Rana Ali, Iolanda Cirillo, Oliver Ackaert   +6 more
wiley   +1 more source

On Stereographic Lognormal Distribution

, 2013
Circular data arise in various walks of life, where we consider the unit circle to be the sample space. Minh &Farnum (2003) developed that Mobius transformation or Stereographic projection is applied to generate probability distributions on real line.
Yedlapalli, Phani, Dattatreya Rao, A.V., Girija, S.V.S.   +2 more
core   +1 more source

Anifrolumab Dose Regimen Selection for a Phase 3 Trial in Lupus Nephritis

Clinical Pharmacology &Therapeutics, EarlyView.
In patients with systemic lupus erythematosus (SLE), increased type I interferon signaling is associated with increased disease activity across organs, including in the kidney, which can cause lupus nephritis (LN). Anifrolumab, which abrogates type I interferon signaling, is an approved treatment for moderate to severe SLE.
Joachim Almquist, Yen Lin Chia, Raj Tummala, Lynn Bertagnolli, David Jayne, Weifeng Tang, Catharina Lindholm   +6 more
wiley   +1 more source

Preconfigured, Skewed Distribution of Firing Rates in the Hippocampus and Entorhinal Cortex

Cell Reports, 2013
Despite the importance of the discharge frequency in neuronal communication, little is known about the firing-rate patterns of cortical populations. Using large-scale recordings from multiple layers of the entorhinal-hippocampal loop, we found that the ...
Kenji Mizuseki, György Buzsáki
doaj   +1 more source

Probabilistic prediction of rate‐dependent rock strength using natural gradient boosting and Gaussian process regression

Deep Underground Science and Engineering, EarlyView.
Probabilistic natural gradient boosting and Gaussian process regression models accurately predict rate‐dependent rock strength across lithologies. Static strength and strain rate dominate, while geometric factors have minimal influence, enabling interpretable and uncertainty‐aware predictions for dynamic geomechanical applications. Abstract The dynamic
Hadi Fathipour‐Azar
wiley   +1 more source

On the Shifted Hybrid Log-Normal Distribution

Statistica
The log-normal distribution is widely used to model positive valued data in many areas of applied research. However, sometimes the log-normal distribution does not completely satisfy the fitting expectations in every real life situations.
Damodaran Santhamani Shibu, Soman Latha Nitin, Muhammed Rasheed Irshad   +2 more
doaj   +1 more source

Lognormal and Pareto distributions in the Internet [PDF]

Computer Communications, 2005
Numerous studies have reported long-tailed distributions for various network metrics, including file sizes, transfer times, and burst lengths. We review techniques for identifying long-tailed distributions based on a sample, propose a new technique, and apply these methods to datasets used in previous reports.
openaire   +1 more source