Results 101 to 110 of about 397,553 (307)

On the Epistemology of Modal Rationalism: the Main Problems and Their Significance [PDF]

open access: yes, 2015
In this paper, I discuss the main characteristics of the epistemology of modal rationalism by proceeding from the critical investigation of Peacocke’s theory of modality.
Rusu, Mihai
core   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

open access: yesAdvanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu   +12 more
wiley   +1 more source

Image as Agency

open access: yesTheoLogica
This essay argues for a dual-aspect, substantival and functional, model of the image of God following the relation of image to agency and to Christ as the exemplar human agent developed in two parts from exegesis to metaphysics.
Jon Kelly
doaj   +1 more source

Weighing the Aim of Belief Again [PDF]

open access: yes, 2017
In his influential discussion of the aim of belief, David Owens argues that any talk of such an ‘aim’ is at best metaphorical. In order for the ‘aim’ of belief to be a genuine aim, it must be weighable with other aims in deliberation, but Owens claims ...
Steglich-Petersen, Asbjørn
core   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan   +16 more
wiley   +1 more source

Relato de experiência com o PNLD Literário favorecendo a mediação da leitura literária e a formação de leitores no ensino médio

open access: yesCadernos Cajuína
O trabalho relata uma experiência pedagógica desenvolvida em uma escola pública de Ensino Médio regular, na qual o acervo do PNLD Literário foi mobilizado para sustentar práticas sistemáticas de mediação da leitura literária e possibilitar a formação de
Ana Reges Pinheiro de Medeiros   +1 more
doaj   +1 more source

Reply to Simion [PDF]

open access: yes, 2017
Mona Simion questions whether there is a distinction between taking back an assertion and taking back only the content of an assertion, as I have claimed. After arguing against the distinction in question, Simion grants that there is a difference between
Kvanvig, Jonathan L.
core   +1 more source

Design and Characterization of DX‐Tile DNA Nanostar‐Based Hydrogels

open access: yesAdvanced Science, EarlyView.
In this study, the authors demonstrated that DNA DX‐tile‐based multi‐arm motifs can be used to assemble pure DNA hydrogels, offering greater design flexibility and enhanced control over their mechanical properties and functionalization capabilities compared to single duplex‐based DNA hydrogels.
Dylan V. Scarton   +13 more
wiley   +1 more source

Knowledge and the Importance of Being Right [PDF]

open access: yes, 2015
Some philosophers have recently argued that whether a true belief amounts to knowledge in a specific circumstance depends on features of the subject’s practical situation that are unrelated to the truth of the subject’s belief, such as the costs for the ...
Fassio, Davide
core   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

open access: yesAdvanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun   +8 more
wiley   +1 more source

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