Results 111 to 120 of about 1,376 (185)

Emerging Fungal Infections of the Central Nervous System in the Past Decade: A Literature Review

Infectious Disease Reports
Introduction: Invasive fungal infections affecting the central nervous system (CNS) are a major health concern worldwide associated with high mortality rates.
Rita Lino, André Rodrigues Guimarães, Estela Sousa, Mariana Azevedo, Lurdes Santos   +4 more
doaj   +1 more source

Novel Antifungal Compounds Discovered in Medicines for Malaria Venture’s Malaria Box

mSphere, 2018
Similarities in fungal and animal cells make antifungal discovery efforts more difficult than those for other classes of antimicrobial drugs. Currently, there are only three major classes of antifungal drugs used for the treatment of systemic fungal ...
Eric H. Jung, David J. Meyers, Jürgen Bosch, Arturo Casadevall   +3 more
doaj   +1 more source

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study

BackgroundOnly a small number of antifungal therapies for invasive fungal disease (IFD) are currently available, and many pathogens are resistant to one or more of these therapies. Olorofim, the first orotomide antifungal agent to be developed, is active
Aguado, Jose Maria, Alexander, Barbara D, Aoun, Mickael, Bazaz, Rohit, Bruns, Anke H W, Brüggemann, Roger J, Chayakulkeeree, Methee, Chen, Sharon C A, Cornelissen, Karen, Cornely, Oliver A, Dane, Aaron, Donovan, Fariba M, Fitton, Lesley, Fortún, Jesus, Georgala, Aspasia, Hammond, Sarah P, Heath, Christopher H, Hoenigl, Martin, Holland, Steven M., Johnson, Royce, Koehler, Philipp, Maertens, Johan A, Mehra, Varun, Mehta, Sanjay R, Miceli, Marisa H, Morrissey, C Orla, Moussa, Mohamed, Nguyen, M Hong, Ostrosky-Zeichner, Luis, Paterson, David L., Patterson, Thomas F, Plate, Markus, Rahav, Galia, Rex, John H., Richardson, Riina, Rijnders, Bart, Ross, Geoffrey G, Schaenman, Joanna, Schwartz, Stefan, Shoham, Shmuel, Sikka, Monica K, Slavin, Monica A, Sole, Amparo, Spec, Andrej, Thompson, George R, Uspenskaya, Olga, Vazquez, Jose A, Veerdonk, Frank L. van de, Verweij, Paul E, Walsh, Stephen R, Walsh, Thomas J, White, P Lewis, Yehudai-Ofir, Dana, Zinzi, Daniela   +53 more
core   +2 more sources

Genetic engineering of cell wall melanin biosynthesis in the emerging human pathogen Lomentospora prolificans [PDF]

, 2017
The dematiaceous (melanised) fungus Lomentospora (Scedosporium) prolificans is a life-threatening opportunistic pathogen of immunocompromised humans, resistant to anti-fungal drugs.
Al-laaeiby, Ayat Ibrahiem Esmaeel
core  

Antifungal Susceptibility Trends Among Filamentous Fungi: An Epidemiological Evaluation on Aspergillus spp., Fusarium spp., and Scedosporium spp. from Southern Italy

Antibiotics
Background/Objectives: Antifungal resistance among filamentous fungi is an increasing global concern with significant implications for clinical management. Herein, we propose a study aiming to investigate in vitro susceptibility patterns and epidemiology
Maddalena Calvo, Marta Caccamo, Dalila Maria Cammarata, Laura Trovato   +3 more
doaj   +1 more source

Development of new strategies for the treatment of emerging opportunistic fungal infections [PDF]

, 2016
Aspergillus fumigatus és el fong filamentós més freqüent i, encara que normalment és sensible als antifúngics, recentment s’han detectat aïllats resistents.
Martín Vicente, Adela
core   +2 more sources

Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice [PDF]

, 2019
We evaluated the efficacy of azithromycin (50 mg/kg, every 12 h [q12h] orally) and miltefosine (25 mg/kg, q24h orally) treatments in an experimental model of vascular/disseminated pythiosis in immunosuppressed mice.
Alves, Sydney Hartz, Azevedo, Maria Isabel de, Jesus, Francielli Pantella Kunz de, Kommers, Glaucia Denise, Loreto, Érico Silva, Santúrio, Jânio Morais, Tondolo, Juliana Simoni Moraes, Verdi, Camila Marina, Weiblen, Carla, Zanette, Regis Adriel   +9 more
core  

Estudio de la resistencia a los antifúngicos en hongos patógenos humanos [PDF]

, 2019
Las mejoras en el diagnóstico, el tratamiento y el cuidado de pacientes inmunodeprimidos han incrementado su tasa de supervivencia, pero también han dado lugar al aumento progresivo de otras enfermedades, como las infecciones fúngicas invasoras.
Rivero Menéndez, Olga
core   +1 more source

The genomes of Scedosporium between environmental challenges and opportunism [PDF]

, 2023
Spina, Federica, Varese, Giovanna Cristina, Venice, Francesco   +2 more
core   +1 more source

<i>Lomentospora prolificans</i> osteomyelitis and septic arthritis in an immunocompromised patient, requiring transhumeral amputation and use of the novel antifungal olorofim. [PDF]

JSES Rev Rep Tech
G O'Donnell T, MacPhail A, Blaser M, Seenarain A, Kidd SE, Halliday CL, Meher-Homji Z, Tran T.   +7 more
europepmc   +1 more source