Results 81 to 90 of about 1,072 (146)

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Airway Mycobiota—Microbiota During Pulmonary Exacerbation of Cystic Fibrosis Patients: A Culture and Targeted Sequencing Study

Mycoses, Volume 68, Issue 1, January 2025.
ABSTRACT Background The airways of patients with cystic fibrosis (pwCF) harbour complex fungal and bacterial microbiota involved in pulmonary exacerbations (PEx) and requiring antimicrobial treatment. Descriptive studies analysing bacterial and fungal microbiota concomitantly are scarce, especially using both culture and high‐throughput‐sequencing (HTS)
Cécile Angebault, Louise‐Eva Vandenborght, Laurence Bassinet, Nathalie Wizla, Agnès Ferroni, Rodrigue Dessein, Natacha Remus, Caroline Thumerelle, Nathalie Fauchet, Ralph Epaud, Laurence Delhaes, Françoise Botterel   +11 more
wiley   +1 more source

N -Chlorotaurine Exhibits Fungicidal Activity against Therapy-Refractory Scedosporium Species and Lomentospora prolificans [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT N -Chlorotaurine (NCT), a well-tolerated endogenous long-lived oxidant that can be applied topically as an antiseptic, was tested on its fungicidal activity against Scedosporium and Lomentospora , opportunistic fungi that cause severe infections with limited ...
Michaela, Lackner, Ulrike, Binder, Martin, Reindl, Beyhan, Gönül, Hannes, Fankhauser, Christian, Mair, Markus, Nagl   +6 more
openaire   +2 more sources

Dihydroorotate dehydrogenase inhibitor F901318 has potent in vitro activity against Scedosporium species and Lomentospora prolificans [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Scedosporium species and Lomentospora prolificans are increasing causes of invasive infections in immunocompromised hosts and many isolates are resistant to available antifungals. Our objective was to assess the in vitro potency of F901318, a member of the orotomide class of antifungals, against Scedosporium species and L.
Nathan P, Wiederhold, Derek, Law, Michael, Birch   +2 more
openaire   +2 more sources

Clinical usefulness of triazole derivatives in the management of fungal infections [PDF]

, 2015
El tratamiento de las infecciones producidas por hongos se limita al uso de un reducido número de moléculas. Si bien, la anfotericina B aún sigue siendo considerada como el antifúngico de referencia, para el tratamiento de estas infecciones, la toxicidad
Arechavala, Alicia, Carrillo Muñoz, Alfonso Javier, Eraso, Elena, Giusiano, Gustavo Emilio, Jauregizar, Nerea, Negroni, Ricardo, Quindós, Guillermo, Tur Tur, Cristina   +7 more
core  

Papel de peptidoramnomananas nas interações polimicrobianas entre espécies de Scedosporium/Lomentospora e bactérias de relevância clínica na fibrose cística [PDF]

, 2022
A fibrose cística é uma doença genética causada pela mutação no gene que codifica a proteína CFTR. Essa desordem gera um desequilíbrio de eletrólitos e água que leva a formação de um muco altamente viscoso nas vias aéreas, que não é facilmente eliminado,
Oliveira, Evely Bertulino de
core  

WHO fungal priority pathogens list to guide research, development and public health action [PDF]

, 2022
Infectious diseases are among the top causes of mortality and a leading cause of disability worldwide. Drug-resistant bacterial infections are estimated to directly cause 1.27 million deaths and to contribute to approximately 4.95 million deaths every ...
Alastruey-Izquierdo, Ana, World Health Organization. Antimicrobial Resistance Division, World Health Organization. Control of Neglected Tropical Diseases, World Health Organization. Global Coordination and Partnership   +3 more
core  

First Record of the Complete Mitochondrial Genome of a Saprotrophic and Opportunistic Human Pathogenic Fungus, Scopulariopsis brevicaulis

Mycobiology, 2020
Scopulariopsis brevicaulis is a widely distributed soil fungus known as a common saprotroph of biodegradation. It is also an opportunistic human pathogen that can produce various secondary metabolites.
Jongsun Park, Woochan Kwon, Seung-Beom Hong, Kap-Hoon Han   +3 more
doaj   +1 more source

Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections

Journal of Fungi, 2020
Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix is the N-phosphonooxymethylene prodrug of manogepix, an inhibitor
Karen Joy Shaw, Ashraf S. Ibrahim
doaj   +1 more source

Isolasi Jamur Kapang dari Tanah [PDF]

Tanah merupakan habitat berbagai mikroorganisme termasuk jamur. Jamur yang hidup di tanah termasuk jamur patogen untuk manusia. Antara lain golongan dermatofita, Aspergillus, dan Mucorales.
Hani, Safira, Hutapea, Ester, Imkotta, Alberto H., Prakasa, Bintang M. Y., Wahyuningsih, Retno   +4 more
core   +2 more sources