Results 51 to 60 of about 2,714,053 (256)

Ripples and undulations in the perceived supply–demand mismatch surfaces of London’s job market

Regional Studies, Regional Science, 2018
In all cities there is a potential for a mismatch to occur between the demand for and supply of jobs. This mismatch is reflective of the balance struck between jobs and housing. This mismatch is non-uniformly perceived by different occupations.
Yao Shen, Michael Batty
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The colibri telescope array for KBO detection through serendipitous stellar occultations: A technical description

Frontiers in Astronomy and Space Sciences, 2022
We present the technical design, construction and testing of the Colibri telescope array at Elginfield Observatory near London, Ontario, Canada. Three 50-cm telescopes are arranged in a triangular array and are separated by 110–160 m.
Michael J. Mazur, Stanimir Metchev, Stanimir Metchev, Rachel A. Brown, Rachel A. Brown, Ridhee Gupta, Richard Bloch, Tristan Mills, Emily Pass   +8 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Numerical Solution of Maxwell Equations for S-Wave Superconductors

Condensed Matter, 2017
The present paper is a sequel to the paper by Karchev (Condensed Matter 20 February 2017). We report the numerical solutions of the system of equations, which describes the electrodynamics of s-wave superconductors without normal quasi-particles for time-
Naoum Karchev, Tsvetan Vetsov
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Environmental factors associated with general practitioner consultations for allergic rhinitis in London, England: a retrospective time series analysis

BMJ Open, 2020
Objectives To identify key predictors of general practitioner (GP) consultations for allergic rhinitis (AR) using meteorological and environmental data.Design A retrospective, time series analysis of GP consultations for AR.Setting A large GP ...
Roger Morbey, Obaghe Edeghere, Gillian Smith, Alex J Elliot, Andre Charlett, Shakoor Hajat, Dan Todkill, Felipe de Jesus Colon Gonzalez, Sari Kovats, Nicholas J Osborne, Rachel McInnes, Sotiris Vardoulakis, Karen Exley   +12 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Investigating the superconducting state of 2H-NbS_{2} as seen by the vortex lattice

Physical Review Research
2H-NbS_{2} is a classic example of an anisotropic multiband superconductor, with significant recent work focusing on the interesting responses seen when high magnetic fields are applied precisely parallel to the hexagonal niobium planes.
A. Alshemi, E. Campillo, E. M. Forgan, R. Cubitt, M. Abdel-Hafiez, E. Blackburn   +5 more
doaj   +1 more source