Results 41 to 50 of about 52,170 (258)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effect of spatial variability in soft soil layers on long-period ground motion amplification [PDF]

E3S Web of Conferences
The Bangkok Basin is characterised by deep alluvial deposits predominantly composed of soft soils, which are highly susceptible to ground shaking induced by distant earthquakes.
Anussornrajkit Pakawadee, Syafrizal Muhammad Disa, Tanapalungkorn Weeradetch, Komolvilas Veerayut, Likitlersuang Suched   +4 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Ground motion prediction equations based on shallow crustal earthquakes in Georgia and the surrounding Caucasus

Earthquake Science, 2022
Strong ground motions caused by earthquakes with magnitudes ranging from 3.5 to 6.9 and hypocentral distances of up to 300 km were recorded by local broadband stations and three-component accelerograms within Georgia’s enhanced digital seismic network ...
Nato Jorjiashvili, Ia Shengelia, Tea Godoladze, Irakli Gunia, Dimitri Akubardia   +4 more
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Simplified engineering geomorphic unit-based seismic site characterization of the detailed area plan of Dhaka city, Bangladesh

Scientific Reports, 2023
Severe failure of improperly designed and poorly constructed structures may occur due to the amplified and prolonged ground motion during an earthquake, and hence prediction of the ground motion characteristics at the soil surface is crucial.
Md Shakhawat Hossain, Muneyoshi Numada, Momtahina Mitu, Kishor Timsina, Chaitaniya Krisna, Md. Zillur Rahman, A. S. M. Maksud Kamal, Kimiro Meguro   +7 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Effects of Soil–Structure Interaction on the Seismic Response of RC Frame–Shear Wall Building Structures Under Far-Field Long-Period Ground Motions

Buildings
This paper focuses on the effect of soil–structure interaction (SSI) on the seismic response of high-rise RC frame–shear wall structures under far-field long-period ground motions. Elastic–plastic time–history analyses were performed using ABAQUS.
Ke Yang, Pengrong Cai, Zixuan Zhang, Qinglin Hou, Ruige Zheng, Bin Hao, Bo Wang   +6 more
doaj   +1 more source

Estimation of the source process and forward simulation of long-period ground motion of the 2018 Hokkaido Eastern Iburi, Japan, earthquake

Earth, Planets and Space, 2020
In this study, we investigate the source rupture process of the 2018 Hokkaido Eastern Iburi earthquake in Japan (M JMA 6.7) and how the ground motion can be reproduced using available source and velocity models.
Hisahiko Kubo, Asako Iwaki, Wataru Suzuki, Shin Aoi, Haruko Sekiguchi   +4 more
doaj   +1 more source