Results 71 to 80 of about 15,157,814 (297)
Remote Sensing, 2015 Vegetation is an important part of terrestrial ecosystems. Although vegetation dynamics have explicit spatial and temporal dimensions, the study of the temporal process is in its infancy.
Xiaoyi Guo +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Fluctuations of stochastic PDEs with long-range correlations
We study the large-scale dynamics of the solution to a nonlinear stochastic heat equation (SHE) in dimensions d≥3 with long-range dependence. This equation is driven by multiplicative Gaussian noise, which is white in time and coloured in space with non ...
Gerolla, Luca +2 more
core +1 more source
A stochastic model of word occurrences in hierarchically structured written texts
SN Applied Sciences, 2022 In previous studies, we have treated real written texts as time series data and have tried to investigate dynamic correlations of word occurrences by utilizing autocorrelation functions (ACFs) and also by simulation of pseudo-text synthesis.
Hiroshi Ogura +3 more
doaj +1 more source
Microscopic models for long ranged volatility correlations [PDF]
Physica A: Statistical Mechanics and its Applications, 2001 12 pages, 4 figures. Proceedings of the NATO Advanced Research Workshop "Application of Physics to Economic Modelling ", Praga (8-10 February 2001).
Giardina, Irene +2 more
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
EntropyVarious fields within biological and psychological inquiry recognize the significance of exploring long-range temporal correlations to study phenomena.
Madhur Mangalam, Aaron D. Likens
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source