Results 361 to 370 of about 4,254,343 (401)

Long-term safety of ketamine and esketamine in treatment of depression

Expert Opinion on Drug Safety, 2022
Introduction Ketamine can produce rapid-acting antidepressant effects. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved by the FDA for treatment-resistant depression in 2019.
Sina Nikayin, Eva L. Murphy, J. Krystal, S. Wilkinson   +3 more
semanticscholar   +1 more source

Long-term treatment of depression

European Neuropsychopharmacology, 1994
In the late 1800's Kraepelin hypothesized that depression had a high probability for recovery. He described depression as acute episodes from which the patient returned to premorbid state of "well-being". It was postulated that there were subgroups who had a recurrent course, but the emphasis was on the theory that between episodes of depression ...
openaire   +6 more sources

Long-term depression with a flash [PDF]

Nature Neuroscience, 1998
The site of expression of hippocampal synaptic plasticity has been hotly debated. A new study demonstrates that postsynaptic neurons alone can express long-term depression.
Robert C. Malenka, Roger A. Nicoll
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Depression in Long-Term Care

Clinical Psychology: Science and Practice, 2005
The assessment and treatment of depression in long-term care (LTC) settings poses unique challenges to both clinicians and researchers. In this review we discuss the variety of forms depression can take among LTC residents and the influence the LTC environment can play on the development and maintenance of depression.
Lee Hyer, Brian Carpenter, Dori Bishmann, Ho-Shyuan Wu   +3 more
openaire   +2 more sources

Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

Science, 2000
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse ...
K. Huber, M. Kayser, M. Bear
semanticscholar   +1 more source

Cerebellar long-term depression: characterization, signal transduction, and functional roles.

Physiological Reviews, 2001
Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other from a set of granule cell axons, are repeatedly associated, the input
Masao Ito
semanticscholar   +1 more source

A model for long-term potentiation and depression

Journal of Computational Neuroscience, 1995
A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential ...
Migliore, M, Alicata, F, Ayala, GF
openaire   +4 more sources

The long-term management of depression

Journal of Psychopharmacology, 1995
The long-term outlook for patients with unipolar depression is often poor. As few as one-fifth will remain well and a similar number will suffer chronic depression. It is now standard practice to extend acute treatment into a 4–6 month period of continuation therapy, and the value of prophylactic treatment over longer periods is becoming more widely ...
openaire   +3 more sources

Calcium signals in long-term potentiation and long-term depression

Canadian Journal of Physiology and Pharmacology, 1999
We describe postsynaptic Ca2+signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+increases of about 50 µM in dendritic spines of CA1 neurons.
Satoru Otani, John A. Connor, Jeffrey J. Petrozzino, Lucas Pozzo-Miller   +3 more
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Long‐term treatment of depression with isocarboxazide

Acta Psychiatrica Scandinavica, 1980
Isocarboxazide has been used as long‐term treatment for a selected group of 20 depressive patients, of whom some 90% (17/19) were non‐responders to treatment with tricyclic antidepressants. At the follow‐up the median duration of illness was 162 months, and the median duration of treatment was 42 months. Side‐effects and interactions were moderate thus
J. K. Larsen, O. J. Rafaelsen
openaire   +3 more sources