Results 91 to 100 of about 3,359,811 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development
Developmental Cognitive Neuroscience, 2015 Metaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the
Daniel G. McHail, Theodore C. Dumas
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Long-term development of express coach services in Britain
, 2012 Express coach services compete for longer distance market with car and rail, and largely cater for the leisure, tourism, and visiting friends and relatives. markets. Britain deregulated its express coach system in 1980, and it is now opportune to examine
Robbins, D., White, P.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Problemy Ekorozwoju, 2014 The discussion was based on the lecture of co-author of the above Report, Dr Stefan Brunnhuber, on common meeting of Poland 2000 Plus Committee for Future Studies, Polish Economic Society and Polish Association for the Club, in Warsaw on 17th of October,
Lesław Michnowski
doaj
Scenarios of the Global and Russian Economic Development as a Basis for S&T Forecasting
Foresight and STI Governance, 2009 The paper provides the analysis of major restrictions and scenarios of long-term (up to 2030) social-economic development of the Russian economy. The authors take into account transformation of the global economic system.
Dmitry Belousov, Alexander Apokin
doaj +1 more source
Long-Term Care Use and Supply in Europe: Projection Models and Results for Germany, the Netherlands, Spain and Poland. ENEPRI Research Report No. 116, April 2012 [PDF]
, 2012 This report presents results of projections of use and supply of long-term care for older persons in four countries representative of different long-term care systems: Germany, the Netherlands, Spain and Poland.
Geerts, Joanna +10 more
core
Inter-American Development Bank Sustainability Report 2013 (Report Summary)
, 2014 Long-term economic growth and the reduction of poverty and inequality in Latin America and the Caribbean depend on development that is both socially inclusive and environmentally sustainable.
Inter-American Development Bank
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source