Results 151 to 160 of about 23,861,944 (302)

Long-term barriers to economic development [PDF]

open access: yes
What obstacles prevent the most productive technologies from spreading to less developed\ud economies from the world’s technological frontier? In this paper, we seek to shed light on this\ud question by quantifying the geographic and human barriers to the transmission of technologies.\ud We argue that the intergenerational transmission of human traits,
Spolaore, Enrico, Wacziarg, Romain
openaire  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer: results from the observational CICARO study. [PDF]

open access: yesOncologist
Kerkmann A   +13 more
europepmc   +1 more source

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