Results 121 to 130 of about 10,105,014 (311)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Long-term prediction of [Formula: see text]Cs in Lake Onuma on Mt. Akagi after the Fukushima accident using fractional diffusion model. [PDF]

Sci Rep, 2021
Suetomi E, Hatano Y, Fujita M, Okada Y, Suzuki K, Watanabe S.   +5 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Long-Term GNSS Satellite Clock Error Forecasting Using Inter-Satellite Comparison Data and RBF Neural Networks

Applied Sciences
Accurate long-term prediction of GNSS satellite clock errors is essential for autonomous navigation, real-time precise point positioning (PPP), and continuous positioning, navigation, and timing (PNT) services when real-time clock products are ...
Tieqiang Liu, Guocheng Wang, Li Liu, Yin Huang, Lintao Liu, Zhiwu Cai, Yu Xiao, Mingyuan Liu, Jianguo Wang   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Long Term Care Ombudsman Annual Report, 1991-1992

, 1992
October 1, 1991 through March 31 ...
Kansas. Long Term Care Ombudsman
core  

Early Identification of the Long-Term Unemployed [PDF]

, 2000
Summary: The paper describes a feasibility study carried out for the Employment Service and the Department for Education and Employment in Britain to identify those individuals who, when first registering as unemployed, are likely to be at high risk of ...
Payne, C., Payne, J.
core  

Long-term temperature prediction with hybrid autoencoder algorithms

Applied Computing and Geosciences
This paper proposes two hybrid approaches based on Autoencoders (AEs) for long-term temperature prediction. The first algorithm comprises an AE trained to learn temperature patterns, which is then linked to a second AE, used to detect possible anomalies ...
J. Pérez-Aracil, D. Fister, C.M. Marina, C. Peláez-Rodríguez, L. Cornejo-Bueno, P.A. Gutiérrez, M. Giuliani, A. Castelleti, S. Salcedo-Sanz   +8 more
doaj   +1 more source

Long-term prediction models for vision-threatening diabetic retinopathy using medical features from data warehouse. [PDF]

Sci Rep, 2022
Jo K, Chang DJ, Min JW, Yoo YS, Lyu B, Kwon JW, Baek J.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source