Results 41 to 50 of about 733,905 (265)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Long‐Term Lithospheric Strength and Upper‐Plate Seismicity in the Southern Central Andes, 29°–39°S

Geochemistry, Geophysics, Geosystems, 2022
We examined the relationship between the mechanical strength of the lithosphere and the distribution of seismicity within the overriding continental plate of the southern Central Andes (SCA, 29°–39°S), where the oceanic Nazca Plate changes its subduction
C. Rodriguez Piceda, M. Scheck‐Wenderoth, M. Cacace, J. Bott, M. R. Strecker   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Estimation of strength of glulam beams depending on defects of layers/Medinių klijuotų lenkiamųjų elementų stiprumo vertinimas pagal sluoksnių defektus

Journal of Civil Engineering and Management, 1999
Timber, as structural material, has various defects, especially knots. They influence the strength of timber members. The influence of knots is lower for glulam members when comparing with solid wood.
Algirdas Baltrušaitis
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

ANALYSIS LAYER MODEL OF POLYMER COMPOSITE DESIGN UNDER MULTIFACTOR LOADING

Вестник Донского государственного технического университета, 2018
A mathematical model is offered for the analysis of complex stress-strain state of the layer load-carrying structures of the aircraft planes. It is presented as sets of the equations of the constraining relations of load parameters, voltages and ...
Oleg G. Osyaev, Yury A. Taturin, Alexey M. Kostin, Artur V. Zhukov   +3 more
doaj  

Factors of the effectiveness of competitive activity of arm wrestlers aged 14-15 years at the stage of preliminary basic training

Слобожанський науково-спортивний вісник
Background and Study Aim. Considering that there are no studies aimed at identifying the components of physical and functional fitness in arm wrestling at the stage of preliminary basic training, and it is not advisable to transfer training of adult ...
Dmytro Bezkorovainyi, Artur Oderov, Kravchenko Anton, Leonid Plotnytskyi, Liudovyk Tetiana, Volodymyr Ozharevskyi   +5 more
doaj   +1 more source