Results 101 to 110 of about 11,411,505 (259)

Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19

Frontiers in Immunology
IntroductionLittle is known about the acute and long-term sequelae of COVID-19 and its pathophysiology in African patients, who are known to have a distinct immunological profile compared to Caucasian populations.
Dawit Wolday, Dawit Wolday, Dawit Wolday, Dawit Wolday, Abrha G. Gebrehiwot, An Nguyen Le Minh, Muhammed Ahmed Rameto, Saro Abdella, Atsbeha Gebreegziabxier, Wondwossen Amogne, Tobias F. Rinke de Wit, Messay Hailu, Getachew Tollera, Geremew Tasew, Masresha Tessema, Matthew Miller, Matthew Miller, Matthew Miller, Amy Gillgrass, Amy Gillgrass, Amy Gillgrass, Dawn M. E. Bowdish, Dawn M. E. Bowdish, Dawn M. E. Bowdish, Dawn M. E. Bowdish, Charu Kaushic, Charu Kaushic, Charu Kaushic, Chris P. Verschoor, Chris P. Verschoor   +29 more
doaj   +1 more source

Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) \u2014 United States, February 12\u2013March 16, 2020

What is already known about this topic?: Early data from China suggest that a majority of coronavirus disease 2019 (COVID-19) deaths have occurred among adults aged 6560 years and among persons with serious underlying health conditions.What is added by ...

core  

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Association Between Acute COVID‐19 Infection and Long COVID in a Non‐Hospitalized Population: A Retrospective Case‐Control Study

Health Science Reports
Background and Aims Long COVID (LC) is a condition characterized by the persistence of physical or psychological symptoms after acute SARS‐CoV‐2 infection.
Nicolás Escrivá, Laura Moreno‐Galarraga, Elena Barado, María Gabriela Torres, Alejandro Fernandez‐Montero   +4 more
doaj   +1 more source

Periodontal disease severity in patients with long COVID and non-COVID-19

Dental Journal
Background: Previous research studies have found the persistence of various COVID-19 symptoms even after the patient tested negative on a PCR test; this incident is now known as long COVID.
Marie Louisa, Alya Amalina, Ricky Anggara Putranto, Olivia Nauli Komala, Wita Anggraini   +4 more
doaj   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Association between COVID-19 Booster Vaccination and COVID-19 Outcomes among U.S. Adults

Vaccines
Understanding the association between booster vaccination and COVID-19 outcomes can help strengthen post-pandemic messaging and strategies to increase vaccination and reduce severe and long-term consequences of COVID-19.
Kimberly H. Nguyen, Cheyenne McChesney, Ruchi Patel, Robert A. Bednarczyk, Lavanya Vasudevan, Laura Corlin   +5 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

A next‐generation vaccine for broader and long‐lasting COVID‐19 protection

MedComm, 2022
Jinxiang Xi, Xiuhua April Si
doaj   +1 more source