Results 61 to 70 of about 11,529,759 (299)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Targeting the SARS-CoV-2 reservoir in long COVID

Lancet. Infectious Diseases (Print)
SUMMARY There are no approved treatments for long COVID, a debilitating condition following SARS-CoV-2 infection that is estimated to affect tens of millions of people.
Amy D. Proal, S. Aleman, Morgane Bomsel, P. Brodin, M. Buggert, Sara R. Cherry, Daniel S. Chertow, Helen E. Davies, Christopher L. Dupont, S. Deeks, E. Ely, A. Fasano, Marcelo Freire, Linda N Geng, Diane E. Griffin, T. Henrich, Stephen M. Hewitt, Akiko Iwasaki, H. Krumholz, M. Locci, Vince C Marconi, S. Mehandru, M. Muller-Trutwin, Mark M. Painter, E. Pretorius, David A. Price, David Putrino, Yu Qian, N. Roan, Dominique Salmon, Gene S. Tan, M. VanElzakker, E. Wherry, J. Van Weyenbergh, L. Yonker, M. Peluso   +35 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Co-design of a voice-based app to monitor long COVID symptoms with its end-users: A mixed-method study

Digital Health
Background People living with Long COVID (PWLC), which is still a poorly understood disease, often face major issues accessing proper care and frequently feel abandoned by the healthcare system.
Aurélie Fischer, Gloria Aguayo, India Pinker, Pauline Oustric, Tom Lachaise, Paul Wilmes, Jérôme Larché, Charles Benoy, Guy Fagherazzi   +8 more
doaj   +1 more source

Long Covid - never ending story

Sri Lanka Journal of Medicine, 2021
No abstract ...
D. Madegedara
doaj   +1 more source

Long Covid – The illness narratives

Social Science & Medicine, 2021
Callard and Perego depict long Covid as the first illness to be defined by patients who came together on social media. Responding to their call to address why patients were so effective in making long Covid visible and igniting action to improve its care, we use narrative inquiry - a field of research that investigates the place and power of stories ...
Alex Rushforth, Emma Ladds, Sietse Wieringa, Sharon Taylor, Laiba Husain, Trisha Greenhalgh   +5 more
openaire   +3 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Four Years in, What Are the Research Priorities for Long COVID? A Research Priority‐Setting Partnership Between People With Lived Experience, Carers, Clinicians and Researchers

Health Expectations
Introduction Long COVID is a life‐limiting condition that affects 65 million people worldwide. It devastates lives with uncertain illness trajectories, and yet, there are many research uncertainties as there is a lack of understanding of its causes ...
Aileen Grant, Emma Stage, David Blane, Helen Goss, Jane Ormerod, Stuart McIver, Edward Duncan, Gail Patel, Abi Campbell, Paul Manson, Ganesh Subramanian, Kay Cooper   +11 more
doaj   +1 more source

Preliminary evidence on long COVID in children

medRxiv, 2021
There is increasing evidence that adult patients diagnosed with acute COVID-19 suffer from Long COVID initially described in Italy. To date, data on Long COVID in children are lacking.
Danilo Buonsenso, D. Munblit, C. De Rose, D. Sinatti, Antonia Ricchiuto, A. Carfì, P. Valentini   +6 more
semanticscholar   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source