Results 81 to 90 of about 850,986 (295)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Hubungan Explosive Power Otot Tungkai dan Kecepatan Lari40 Yarddengan Hasil Lompat Jauh Gaya Jongkoksiswa Putra Kelas V Sdn 010 Rambah Kab. Rohul [PDF]
, 2016 Based on the researcher's of male students in grade V SDN 010 Rambah while do long jump, research found while student do running start was not optimal.
Fitri, D. (Danel) +2 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Sport and Fitness Journal, 2014 Success in the long jump is strongly influenced by the explosive power of the leg muscles. Increasing this explosive power will increase the distance long jump performance.
I Wayan Sugianta +2 more
doaj
Systems and Soft ComputingThere are issues in current higher education long jump teaching, e.g., assessment relies on teachers' experience, lacks scientific evaluation, and can't quantitatively give performance feedback to students.
Tao Wang
doaj +1 more source
Parametric modeling of sports prostheses based on the flat spring design formulas
Journal of Biomechanical Science and Engineering, 2019 Sports prosthesis for lower-extremity amputees has a mechanical structure similar to flat springs, and its elastic energy is expected to improve sports performance. However, it is quite challenging to represent the mechanical phenomena during the takeoff
Kazunori HASE +3 more
doaj +1 more source
From the long jump random walk to the fractional Laplacian
, 2009 This note illustrates how a simple random walk with possibly long jumps is related to fractional powers of the Laplace operator. The exposition is elementary and self-contained.Comment: Submitted to the Probability Surveys (http://www.i-journals.org/ps/)
Valdinoci, Enrico
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Dynamics of the flip long jump
Physics Education, 2023 Abstract The long jump is a track and field event in which athletes attempt to jump as far as possible from a take-off point into a sandpit. In the 1970s, an athlete called Tuariki Delamere tried to introduce a ‘front flip’ technique where one goes into a front tuck instead of using a regular technique like the hitch kick and argued that
openaire +2 more sources