Results 71 to 80 of about 7,808,961 (245)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

AstraNav-Memory: Contexts Compression for Long Memory

CoRR
Lifelong embodied navigation requires agents to accumulate, retain, and exploit spatial-semantic experience across tasks, enabling efficient exploration in novel environments and rapid goal reaching in familiar ones. While object-centric memory is interpretable, it depends on detection and reconstruction pipelines that limit robustness and scalability.
Botao Ren, Junjun Hu, Xinda Xue, Minghua Luo, Jintao Chen, Haochen Bai, Liangliang You, Mu Xu   +7 more
openaire   +3 more sources

Olfactory Memory: the Long and Short of It [PDF]

Chemical Senses, 1998
It has been proposed that memory for odors does not have a short-term (or working) memory system. The distinction between short- and long-term memory in other sensory modalities has been generally supported by three main lines of evidence: capacity differences between the proposed systems, evidence of differential coding, and differential memory losses
openaire   +2 more sources

Capturing Long-Range Dependence and Harmonic Phenomena in 24-Hour Solar Irradiance Forecasting: A Quantile Regression Robustification via Forecasts Combination Approach

IEEE Access, 2020
The global horizontal irradiance data recorded at the earth's horizontal surface is a mixture of deterministic (extra-terrestrially) and stochastic components due to the ever-changing atmospheric conditions. The Box-Jenkins short memory stochastic models
Edmore Ranganai, Caston Sigauke
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Is Working Memory a Gateway to Long-Term Memory?

Journal of Experimental Psychology: General
Working memory (WM) has been proposed to act as a gateway into long-term memory (LTM), such that only information successfully stored in WM can be transferred into LTM. Accordingly, the capacity limit of WM should constrain the acquisition of LTM traces.
Bartsch, Lea, Souza, Alessandra S., Mizrak, Eda, Oberauer, Klaus   +3 more
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

TÜRKİYE’DE SATIN ALMA GÜCÜ PARİTESİ HİPOTEZİNİN GEÇERLİLİĞİ: UZUN HAFIZA TESTLERİNDEN KANITLAR

Mehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2018
Esnekkur rejiminin küresel anlamda yaygınlaşmasıyla birlikte döviz kuru öngörüsü deönem kazanmaya başlamıştır. Döviz kurları, başta dış ticaret dengesi olmaküzere, yatırım kararlarının alınmasında ve küresel gelirden daha fazla payalabilmek için merkez ...
İsmail Çelik, Harun Kaya
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source