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The long QT syndrome

Current Problems in Cardiology, 1980
The still inadequate but increasing awareness of the existence of the idiopathic long QT syndrome (LQTS) has provided ample evidence that, as suggested by many, this disease is far from being rare. This notion, coupled with the unusual pathophysiological characteristics and with the high degree of lethality in untreated patients, explains why the LQTS ...
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LONG QT SYNDROME

Cardiology Clinics, 2000
In conclusion, much has been learned in the past several years regarding the molecular biology of LQTS, and this information has been directly applicable to the clinical care of patients with this syndrome. The knowledge also has been of considerable importance for understanding the molecular basis of arrhythmias in general and is providing insights ...
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Long QT Syndrome and Short QT Syndrome

Progress in Cardiovascular Diseases, 2008
The long QT syndrome (LQTS) is a genetic disorder characterized by prolongation of the QT interval in the electrocardiogram (ECG) and a propensity to torsades de pointes ventricular tachycardia frequently leading to syncope, cardiac arrest, or sudden death usually in young otherwise healthy individuals.
Wojciech, Zareba, Iwona, Cygankiewicz
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Significance of QT dispersion in the long QT syndrome

Progress in Cardiovascular Diseases, 2000
The long QT syndrome (LQTS) has often been considered as a model to study the abnormalities of cardiac repolarization in humans because it represents a pure electrical disease with no evidence of cardiac structural abnormalities. The arrhythmogenic potential of prolonged ventricular repolarization has been extensively studied both in experimental ...
Napolitano C   +2 more
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Long QT syndrome

Heart Rhythm
Key Points Long QT Syndrome Long QT syndrome is a leading cause of sudden death in young persons, with a prevalence exceeding 1 in 2000. It is characterized by prolongation of the QT interval, aberrant T-wave morphologic features, and the propensity toward life-threatening arrhythmias triggered mostly by adrenergic activation.
Schwartz P. J., Crotti L.
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Long QT syndromes

Current Treatment Options in Cardiovascular Medicine, 2000
The clinical phenotype of the long QT syndrome (LQTS) is quite variable, with the frequency and type of life-threatening arrhythmias influenced by the specific genotype and a spectrum of genetic and environmental factors that are not well characterized.
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Long QT syndrome in children

Journal of Electrocardiology, 2001
The long QT syndrome (LQTS) is a congenital disorder characterized by a prolongation of the QT interval on electrocardiogram and a propensity to ventricular tachyarrhythmias, which may lead to cardiac events defined as syncope, cardiac arrest, or sudden death. Children are very frequently affected by LQTS accounting for about 50% of probands and 40% to
W, Zareba, A J, Moss
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Famotidine and long QT syndrome

The American Journal of Cardiology, 2004
Numerous drugs have been implicated in causing a prolonged QT interval and Torsades de pointes. However, the association of famotidine and acquired long QT syndrome has rarely been reported. We report 2 cases of famotidine-associated acquired long QT syndrome.
Ken W, Lee   +4 more
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The Long QT Syndrome

Heart, Lung and Circulation, 2007
The long QT syndrome (LQTS) is a genetically transmitted cardiac arrhythmia due to ion channel protein abnormalities, which affects the transport of potassium and sodium ions across the cell membrane. Patients with LQTS may present with syncope, seizures or aborted cardiac arrest.
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Long QT syndrome and anaesthesia

European Journal of Anaesthesiology, 2002
The long QT syndrome is a disorder of myocardial electrical conduction that leaves the heart vulnerable to the ventricular tachydysrhythmia torsade de pointes. Clinically, this results in syncope or sudden death. The long QT syndrome may be congenital, if caused by abnormal myocardial potassium or sodium ion channels, or acquired, if due to drugs ...
N A, Wisely, E A, Shipton
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