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Results 121 to 130 of about 25,582,243 (263)

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source

MCMC-Based Bayesian Estimation for Nonlinear Mixed-Effects Models with Missing Data: A Study of Convergence and Computational Efficiency

Mathematics
Bayesian estimation of nonlinear mixed-effects models typically relies on Markov-Chain Monte Carlo (MCMC) methods due to the intractability of the posterior distribution.
Lulah Alnaji
doaj +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani +10 more
wiley +1 more source

Artificial Intelligence-Based Models for Predicting Disease Course Risk Using Patient Data

Computers
Nowadays, longitudinal data are common—typically high-dimensional, large, complex, and collected using various methods, with repeated outcomes. For example, the growing elderly population experiences health deterioration, including limitations in ...
Rafiqul Chowdhury +4 more
doaj +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane +19 more
wiley +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source

Studying school communities as multiplex dynamic networks: The “RECENS Wired into Each Other” Dataset, 2010–2013

Connections
This article provides an overview of the “Research Center for Educational and Network Studies (RECENS) Wired into each other” longitudinal social network study conducted in 44 secondary-school classrooms in Hungary between 2010 and 2013.
Vörös András +6 more
doaj +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source

Heterogeneous trajectories of executive function in clinical Alzheimer's disease: Results from the 3C study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
BACKGROUND Alzheimer's disease (AD) shows considerable heterogeneity in cognitive decline. Executive function (EF), a core cognitive domain, may contribute to this heterogeneity and modulate AD progression. METHODS We analyzed the trajectories of four EF‐
Hélène Amieva +11 more
doaj +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle +4 more
wiley +1 more source

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