Results 41 to 50 of about 229,943 (347)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A Static Stability Analysis Method for Passively Stabilized Sounding Rockets

Aerospace
Sounding rockets constitute a class of rocket with a generally simple layout, being composed of a cylindrical center-body, a nosecone, a number of fins placed symmetrically around the longitudinal axis (usually three or four), and possibly a boat-tail ...
Riccardo Cadamuro, Maria Teresa Cazzola, Nicolò Lontani, Carlo E. D. Riboldi   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Lateral-Directional Aerodynamic Optimization of a Tandem Wing UAV Using CFD Analyses

Aerospace
This paper presents the second stage of a tandem fixed-wing unmanned aerial vehicle (UAV) aerodynamic development. In the initial stage, the UAV was optimized by analyzing its characteristics only in symmetrical flight conditions.
Ivan Kostić, Aleksandar Simonović, Olivera Kostić, Dušan Ivković, Dragoljub Tanović   +4 more
doaj   +1 more source

Low Speed Wind Tunnel Test of a Blended Wing Body Configuration

Hangkong gongcheng jinzhan, 2019
Blended wing body(BWB) configuration will be the inevitable trend of the aircraft using in the future civil aviation for its excellent performance. Aerodynamic and flow mechanism investigations of the BWB configuration will provide important support for ...
Li Peifeng, Zhang Binqian, Tao Yujin, Li Dong   +3 more
doaj   +1 more source

The longitudinal static stability of an aerodynamically alleviated marine vehicle, a mathematical model [PDF]

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2009
An assessment of the relative speeds and payload capacities of airborne and waterborne vehicles highlights a gap that can be usefully filled by a new vehicle concept, utilizing both hydrodynamic and aerodynamic forces. A high-speed marine vehicle equipped with aerodynamic surfaces is one such concept.
Collu, Maurizio, Patel, Minoo H., Trarieux, Florent   +2 more
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Effects of design parameters on longitudinal static stability for WIG craft

International Journal of Aerodynamics, 2010
The longitudinal stability characteristics of a wing-in-ground effect (WIG) craft are quite different from that of conventional airplane due to the existence of ground effect. The effects of design parameters including wing section, stabiliser, wing planform and endplate on longitudinal static stability of WIG craft were studied based on numerical ...
Wei Yang, Zhigang Yang, Chengjiong Ying
openaire   +1 more source