Results 241 to 250 of about 23,557 (297)

The next paradigm in bioinformatics: a review of multi-agent systems and foundational models for end-to-end scientific discovery. [PDF]

Brief Bioinform
Branda F, Ahmed MM, Ciccozzi M, Guzzi PH, Scarpa F.   +4 more
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Characterization of Squeeze Film Damping in Force Rebalance Accelerometers. [PDF]

Sensors (Basel)
Özmen HB, Şahin M, Özgen GO.
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Towards More Efficient Loop Checks.

, 1990
openaire   +1 more source

'It'd Be Nice to Know if You're About to Have Drain Cleaner': A Qualitative Study of Preferred Drug Checking Service Features to Inform the Design of CheQpoint, Queensland's First Fixed-Site Drug Checking Service. [PDF]

Drug Alcohol Rev
Puljević C, Pocuca N, Dakin BC, Barratt MJ, Francis C, Stjepanović D, Gill S, Davey G, Hides L.   +8 more
europepmc   +1 more source

Online Friction Measurement and Wear-Life Determination for Textile Needle Hooks Based on Closed-Loop Tension Control and the Capstan Model. [PDF]

Sensors (Basel)
Chen Y, Zeng Y, Xu W, Gan H, Xiao M, Zhu J, Wu Y, Wang P, Mei S, Yu L.   +9 more
europepmc   +1 more source

Best-first search-based approach for mining top-k closed frequent itemsets from uncertain databases. [PDF]

PLoS One
Le N, Vo H, Nguyen T.
europepmc   +1 more source

Drug checking services: barriers and facilitators to implementation by U.S. syringe services programs. [PDF]

Harm Reduct J
Smith J, Philbrick SM, Akiba CF, Wenger LD, Hairgrove S, Kral AH, Lambdin BH, Patel SV.   +7 more
europepmc   +1 more source