Results 151 to 160 of about 331,908 (277)

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

A complexity transition in displaced Gaussian Boson sampling. [PDF]

npj Quantum Inf
Li Z, Solomons NR, Bulmer JFF, Patel RB, Walmsley IA.   +4 more
europepmc   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Anisotropically Wettable Porous Transport Layers for Gas Management in Water Electrolyzers

Advanced Science, EarlyView.
Synergistic wetting, achieved by integrating hydrophilic and hydrophobic domains, enhances mass transport in porous transport layers. In situ visualization reveals that dual‐phase wetting suppresses gas accumulation and promotes continuous bubble release, enabling stable, bubble‐free electrolysis within membrane electrode assemblies.
Yunseok Kang, Seunghyun Lee, Jinseo Lee, Soi Lee, Geonwoo Lee, Hyeongoo Kim, Gwan Hyun Choi, Jungki Ryu, Dong Woog Lee   +8 more
wiley   +1 more source

Decoding RNA Structural Ensembles: Energy Landscape Exploration of the TAR Stemloop. [PDF]

J Chem Theory Comput
Röder K.
europepmc   +1 more source

A Degradable Bioinspired Flier with Aerogel‐Based Colorimetric Sensors for Environmental Monitoring

Advanced Science, EarlyView.
Biodegradable fliers are developed inspired by Tipuana tipu samaras, integrating cellulose nanocrystal aerogel (CNCa) sensors loaded with natural dyes for pH and ammonia detection. The lightweight, degradable fliers mimic natural morphology and aerodynamics, offering an eco‐friendly, scalable solution for in situ environmental monitoring after passive ...
Gianpaolo Gallo, Ruowen Tu, Carlo Filippeschi, Stefano Mariani, Barbara Mazzolai   +4 more
wiley   +1 more source

WatCon: A Python Tool for Analysis of Conserved Water Networks Across Protein Families. [PDF]

JACS Au
Brownless AR, Harrison-Rawn T, Kamerlin SCL.   +2 more
europepmc   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Long-term susceptible fractions in networked epidemic models and their relation to the basic reproduction number. [PDF]

Sci Rep
Khong SZ, Su L, Georgiou T.
europepmc   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source