Results 61 to 70 of about 332,988 (266)
Kidney and Blood Pressure Research, 1987 Loop diuretics such as furosemide, piretanide, and bumetanide bind reversibly to the Na<sup>+</sup>2Cl<sup>-</sup>K+ carrier. This transporter is responsible for the uptake of Cl<sup>-</sup> into the thick ascending limb segment.
R, Greger, P, Wangemann
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Loop-check free sequent calculi for unary fragment of temporal logic
Lietuvos Matematikos RinkinysThis paper explores the construction of an efficient sequent calculus for a selected fragment of porpositional linear temporal logic (PLTL), extending the ideas of classical calculi discussed in [1], and builds upon previous investigations into the ...
Lukas Maksimiak, Adomas Birštunas
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Un paseo por los anillos de bucles
Revista Integración, 2012 La teoría de anillos de bucles no es solamente una generalización de los anillos de grupos: es una teoría en sí misma, con origen y aún en movimiento. El concepto de anillo de bucles surge en 1944 en los trabajos de R.H.
Carmen Rosa Giraldo Vergara
doaj
Novel BPS Wilson loops in three-dimensional quiver Chern–Simons-matter theories
Physics Letters B, 2016 We show that generic three-dimensional N=2 quiver super Chern–Simons-matter theories admit Bogomol'nyi–Prasad–Sommerfield (BPS) Drukker–Trancanelli (DT) type Wilson loops.
Hao Ouyang, Jun-Bao Wu, Jia-ju Zhang
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source