Results 81 to 90 of about 108,374 (241)

Effect of Rainfall Intensity and Stone Content on the Instability of Quaternary Deposits

工程科学与技术, 2019
The geological processes, including earthquake, engineering excavation, weathering, erosion and transport caused a large number of loose accumulation bodies. The stone content in these loose accumulation bodies were different, and the instability induced
Peifeng HAN, Xiaoyi FAN, Shujun TIAN, Youyi ZHANG   +3 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Lower Body Compression Garments on Hemodynamics in Response to Running Session

The Scientific World Journal, 2014
Purpose. Compression garments are often worn during exercise and allegedly have ergogenic and/or physiological effects. In this study, we compared hemodynamics and running performance while wearing compression and loose-fit breeches. We hypothesized that
Tomas Venckūnas, Eugenijus Trinkūnas, Sigitas Kamandulis, Jonas Poderys, Albinas Grūnovas, Marius Brazaitis   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Study on gas seepage characteristics of loose coal

Meikuang Anquan
In order to study the influence of temperature on the gas seepage law in loose coal bodies in goaf, gas seepage characteristics experiments were conducted on three types of coal samples, namely anthracite, bituminous coal, and lignite, under different ...
Xuezhao ZHENG, Yongchao FAN, Ruijin YAN, Ziyu SUN, Yuan HUANG   +4 more
doaj   +1 more source

Arthroscopic and Endoscopic Technique for Subcoracoid Synovial Chondromatosis of the Shoulder Through a Medial Transpectoral Portal

Arthroscopy Techniques, 2018
Synovial chondromatosis of the shoulder is a rare disorder characterized by metaplastic synovial proliferation, causing multiple loose bodies usually localized intra-articularly.
Mikel Aramberri, M.D., Ph.D., Giovanni Tiso, M.D., David L. Haeni, M.D.   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mathematical Simulation of Effect of 7 t Steel Ingot Shape Body Height on Solidification Process and Metallurgical Qulity

Teshugang, 2018
The ingot shape has certain influence on the defects such as porosity and shrinkage in the solidification process of ingot. Based on body height 2 075 mm long and slim shape (B) and 1 885 mm short and thick shape ( A) two kinds of 7 t ingot, by casting ...
肖卿鹤, 李胜利, 艾新港, 韩昆, 沙明红, 张连望   +5 more
doaj  

Primary Synovial Chondromatosis of the Hip Joint: A Case Report

Journal of Orthopaedic Case Reports
Introduction: Primary synovial chondromatosis (PSC) is a rare benign disorder characterized by cartilaginous nodule formation within synovial tissue. Hip joint involvement is uncommon, and optimal surgical management remains debated.
Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source