Results 141 to 150 of about 5,136 (294)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
A Tolkien Tapestry : Interwoven Epic Threads in J.R.R. Tolkien\u27s The Lord of the Rings [PDF]
, 1996 This thesis argues for greater respect for J.R.R. Tolkien\u27s novel The Lord of the Rings by tracing its connections to the world\u27s great epics. The author analyzes significant groups of characters to illustrate their concurrence with the traditional
Jalowitz, Alan Christopher
core
Enter Middle-earth: A Comparison of The Lord of the Rings Online with The Lord of the Rings
, 2022 The purpose of this study has been to explore how the story in The Lord of the Rings is experienced in the game, The Lord of the Rings Online, compared to the book. The focus has been on the concepts of narrative, interaction, immersion, and themes. I have used my own experience from the game in addition to other academic sources when I have examined ...
openaire +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Translating Archaic Style in The Lord of the Rings [PDF]
This MA thesis examines the usage of style in translation from English to Finnish, more specifically archaisms as a style strategy in fantasy fiction.
Keskinen, Onni
core
Theodicies in The Lord of the Rings
, 2020 This article focuses on the theodicy concept that emerges from the work construction of The Lord of the Rings, by J. R. R. Tolkien. We compared the theorization issued by Collin Campbell regarding a supposed western theodicy change, which was being influenced in culture and religion to adhere to a concept of epistemologically oriental origin.
Follis, Rodrigo +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source