Results 31 to 40 of about 5,136 (294)

The Lord of the Rings” and the World Wars: The Applicability of Allegory [PDF]

open access: yes, 2013
"Lord of the Rings" trilogy, written by John Ronal Reuel Tolkien between 1937 and 1949 is an epic novel, set in the fictional Middle Earth, in which a brotherhood of humans, elves and dwarves battles against a mighty force of evil, Sauron and his minions
Tandoğan, Sinan Haluk
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Recovery, escape and consolation in the secondary worlds of The Lord of the Rings [PDF]

open access: yes, 2008
Includes bibliographical references (leaves 96-100).J.R.R. Tolkien's essay "On Fairy-Stories" lays out three essential functions that all good fairy stories should fulfil: recovery, escape, and consolation.
Hazekamp, Robyn
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Tolkien w oczach mediewisty

open access: yesCreatio Fantastica, 2018
The Lord of the Rings, ever since its publication, has been something of a nuisance to traditional literary critics and has been maligned often and with zest.
Thomas Honegger
doaj   +1 more source

Framing audience prefigurations of The Hobbit: An Unexpected Journey: The roles of fandom, politics and idealised intertexts [PDF]

open access: yes, 2014
Audiences for blockbuster event-film sequels and adaptations often formulate highly developed expectations, motivations, understandings and opinions well before the films are released.
Hight, Craig   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Tripping the light fantastic: exploring the imaginative geographies of Lord of the Rings ‘film tourism’ in New Zealand [PDF]

open access: yes, 2009
From screen image to imagined spaces, the Lord of the Rings film-tourism experience – that is, tourism to New Zealand apparently motivated by the popular film trilogy which was filmed there – has received much anecdotal attention, yet little scholarly ...
FIRNIGL, DANIELLE,ELIZABETH   +1 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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