Results 131 to 140 of about 27,152 (260)

Dispersal, source and glass chemistry of a third tephra unit within Iceland's Settlement Layer

open access: yesBoreas, EarlyView.
Tephra layers may be studied to understand the dynamics and sequence of past explosive volcanism. In Iceland, the distinctive Settlement Layer (AD ~877) underlies almost all archaeological evidence for the Norse Settlement and is preserved in soils across Iceland and as cryptotephra overseas.
Conner A. G. Morison   +3 more
wiley   +1 more source

Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting

open access: yesBrain Pathology, EarlyView.
Using the Infinium MethylationEPIC v2.0 array and Heidelberg Brain Tumor Classifier v12.8, 24 international laboratories achieved highly reproducible CNS tumor classification (97.9% correct; median β‐correlation r = 0.99), while copy number variation interpretation showed substantial interlaboratory variability, highlighting the need for harmonized CNV
Katrin Mauch‐Mücke   +50 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

FPGA realization of fractional-order chaotic oscillators using ABM and EFORK methods. [PDF]

open access: yesSci Rep
Pérez JCN   +4 more
europepmc   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer   +5 more
wiley   +1 more source

Chaotic and complex dynamics expose the limits of counterfactual reasoning. [PDF]

open access: yesSci Rep
Aalaila Y   +4 more
europepmc   +1 more source

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann   +7 more
wiley   +1 more source

‘Be There, Listen, See What It Is They Need’: Fathers' Roles in Supporting Black Mothers During Pregnancy

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT There is a critical public health crisis regarding the infant mortality rate between black and white mothers in the USA. This issue is more pronounced in North Carolina, where black infants have a much higher infant mortality rate than whites.
Jeffrey Shears   +7 more
wiley   +1 more source

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