Results 41 to 50 of about 450,923 (287)
Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans‐Cleavage for Rapid and Sensitive Nucleic Acid Detection
Advanced Science, EarlyView.We uncover dual CRISPR‐Cas12a trans‐cleavage activities: endonucleolytic cleavage and 3′→5′ exonucleolytic trimming of ssDNA reporters. Mechanism‐guided 3′‐phosphate engineering accelerates substrate cleavage while favoring endonucleolytic processing, enabling Phos‐CRISPR, a rapid (20 min), highly sensitive, and specific platform for nucleic acid ...Rui Yang, Chong Guo, Minjie Pei, Jiongyu Zhang, Xin Guan, Shuo Zhang, Xingye Liu, Kurt T. Schalper, Lori Avery, Rocco LaSala, David Banach, Changchun Liu +11 morewiley +1 more sourceLorraine Aanerud Interview, 1995 [PDF]
, 1995 In this interview, Lorraine Aanerud reminisces about the early days of television. Ms. Aanerud was born in Stevens County in 1935. Her family purchased their first television set in 1955.https://digitalcommons.morris.umn.edu/tvoralhistories/1038 ...Aanerud, Lorrainecore +2 more sourcesA Damage‐Gated Small‐Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...Ratislav M. Ozhiganov, Ekaterina А. Guseva, Alexander Yu. Rudenko, Konstantin G. Lyamzaev, Sofya Y. Sokolskaya, Julia A. Golubeva, Maria V. Belopolskaya, Nadezda V. Andrianova, Olga V. Fadeeva, Elena О. Morgun, Elena A. Tukhovskaya, Marina S. Kazakova, Vladimir M. Pavlov, Daria K. Yagoda, Elena I. Marusich, Rose‐Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, Egor Y. Plotnikov, Maxim L. Lovat, Lora E. Bakeeva, Arkady N. Murashev, Vladimir I. Polshakov, Olga A. Dontsova, Peter V. Sergiev +24 morewiley +1 more sourceNational and International Monitoring of Student Literacy and Numeracy Attainment: The Case for Rigorous Macro and Micro Analysis
Australian Journal of Social Issues, EarlyView.ABSTRACT
In her 2024 paper Are Australian students' academic skills declining? Interrogating 25 years of national and international standardised assessment data, Larsen compiled an impressive summary of major international (PISA, PIRLS and TIMSS) and national (NAPLAN) standardised assessments pertaining to literacy and numeracy.Pamela C. Snow, Tanya A. Serry, Jennifer Buckingham, Lorraine S. Hammond, Stephen Dinham, Eamon Charles, Tessa A. Weadman, Nathanial R. Swain, Susan Hiland, Tessa Daffern +9 morewiley +1 more sourceUnderstanding the Pattern of Cognitive Decline in GBA1‐Related Parkinson's Disease: An Exploratory Longitudinal Multi‐Cohort Study
Annals of Neurology, EarlyView.Objective
People with Parkinson's disease (PD) who carry a pathogenic GBA1 variant (PDGBA1) are at higher risk of cognitive impairment than those without the variant (PDGBA1_wildtype). To date, little is known about the pattern and evolution of cognitive decline in PDGBA1. This multicenter study characterized the cognitive profile of PDGBA, focusing on Merle Bode, Claire Pauly, Sonja Rós Jónsdóttir, Claudia Schulte, Sara Becker, Isabel Wurster, Benjamin Roeben, Stefanie Lerche, Werner Poewe, Rejko Krüger, Inga Liepelt‐Scarfone, Kathrin Brockmann, on behalf of the NCER‐PD consortium, the Parkinson's Progression Markers Initiative, Kenneth Marek, Tanya Simuni, Andrew Siderowf, Caroline Tanner, Thomas F. Tropea, Tatiana Foroud, Lana Chahine, Brit Mollenhauer, Kalpana Merchant, Douglas Galasko, Christopher Coffey, Kathleen Poston, Roseanne Dobkin, Ethan Brown, Roy Alcalay, Dan Weintraub, Emily Flagg, Kimberly Fabrizio, Susan Bressman, Cornelis Blauwendraat, Paola Casalin, Sonya Dumanis, Raymond James, Karl Kieburtz, Sneha Mantri, Werner Poewe, Michael Schwarzschild, John Seibyl, David Standaert, Duygu Tosun‐Turgut, Sohini Chowdhury, Jamie Eberling, Mark Frasier, Leslie Kirsch, Katie Kopil, Maggie Kuhl, Alyssa O’Grady, Todd Sherer, Tawny Willson, Emily Flagg, Tanya Simuni, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Christine Kohnen, Tatiana Foroud, Laura Heathers, Christopher Hobbick, Gena Antonopoulos, John Seibyl, Kathleen Poston, Christopher Coffey, Chelsea Caspell‐Garcia, Michael Brumm, Arthur Toga, Karen Crawford, Tatiana Foroud, Jan Hamer, Brit Mollenhauer, Doug Galasko, Kalpana Merchant, Andrew Singleton, Tatiana Foroud, Dirk Keene, Ethan Brown, Carlie Tanner, Ethan Brown, Lana Chahine, Roseann Dobkin, Monica Korell, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Sebastian Schade, Douglas Galasko, Anat Mirelman, Roy Alcalay, Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber, Joy Antala, Carla Aranda, Karen Williams, Sophia Melton, Karina Benson, Ashwini Ramachandran, Danielle Potts, Grace LaMoure, Ritikha Vengadesh, Ryan Manzler, Jaime Heller, Primi Ranola, Farah Kausar, Sherri Mosovsky, Diana Willeke, Elizabeth Kalinkara Gomez, Janelle Rodriguez, Nobuko Kemmotsu, May Eshel, Deborah Raymond, Abigail Desrosiers, Raymond James, Lauren Jackson, Iris Egner, Wesley Schlett, Courtney Blair, Lauren Ruffrage, Berenice Sevilla, Barbara Sommerfeld, Dustin Le, Erica Botting, Gabriella Mazur, Daniele Derlein, Evan Doll, Ying Liu, Ciera Cobb, Olivia Masiewicz, Jennifer Mule, Michael Morsillo, Ella Hilt, Aldazier Jakiran, Dominga Valentino, Lisbeth Pennente, Bobbie Stubbeman, Alicia Garrido, Valeria Ravasi, Ioana Croitoru, Christos Koros, Nikolas Papagiannakis, Frank Ferrari, Mengyu Zheng, Shawna Reddie, Alicia Alejandra, Andrea Gray, Alejandra Valenzuela, Caitlin Goodman, Sara Dresler, Neil Santos, Fahrial Esha, Kyle Rizer, Nadine Zablith, Liliana Dumitrescu, Debra Galley, Victoria Kate Foster, Jamil Razzaque, Madita Grümmer, Yara Krasowski, Natalie Donkor, Elisabeth Sittig, Oluwadamilola Ojo, Kelly Clark, Rory Mahabir, Kori Ribb, Shamera Willoughby, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlann, Anne Grünewald, Armin Rauschenberger, Clarissa P. C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez De Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby. +345 morewiley +1 more sourceMechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial
Annals of Neurology, EarlyView.Objective
This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core identified before transfer.Pierre Seners, Adrien ter Schiphorst, Julien Labreuche, Bertrand Lapergue, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sébastien Richard, Jean‐François Albucher, Christophe Cognard, Liesjet E.H. van Dokkum, David S. Liebeskind, Tudor G. Jovin, Vincent Costalat, Caroline Arquizan, for the LASTE investigators, Caroline Arquizan, Vincent Costalat, Xavier Ayrignac, Mahmoud Charif, Lucas Corti, Cyril Dargazanli, Imad Derraz, Nicolas Gaillard, Grégory Gascou, Pierre‐Henri Lefevre, Anaïs Lippi, Isabelle Mourand, Pauline Prin, Perrine Schmitt, Florian Savenier, Adrien Ter Schiphorst, Igor Sibon, Gaultier Marnat, Pierre Briau, Florent Gariel, Jean‐Sébastien Liegey, Malgorzata Milnerowicz, Jean Papaxanthos, Lisa Papillon, Sophie Godard, Anne Pasco‐Papon, Alice Corfu, Jean‐Baptiste Girot, Vincent L'Allinec, Alderic Lecluse, Matthias Lamy, Stéphane Velasco, Nadeem Beydoun, Samy Boucebci, Victor Dumas, Cédric Fauche, Jean‐Philippe Neau, Paola Palazzo, Nicolas Raynaud, Emmanuel Houdart, Mikael Mazighi, Agnès Aghetti, Anna Dimitrovic, Alexis Guedon, Peggy Reiner, Olivier Naggara, Guillaume Turc, Wagih Benhassen, Basile Kerleroux, Christine Rodriguez Regent, Frédéric Clarencon, Sonia Alamowitch, Julien Allard, Flore Baronnet, Sophie Crozier, Stephen Delorme, Sandrine Deltour, Gaspard Gerschenfeld, Anne leger, Kevin Premat, Charlotte Rosso, Yves Samson, Eimad Shotar, Laurent Spelle, Christian Denier, Jildaaz Caroff, Vanessa Chalumeau, Olivier Chassin, Sophie Gallas, Léon Ikka, Nicolas Legris, Mariana Sarov Riviere, Laura Venditti, Benjamin Gory, Sébastien Richard, René Anxionnat, Mathieu Bonnerot, Liang Liao, Nolwenn Riou‐Comte, Romain Bourcier, Benoît Guillon, Pierre‐Louis Alexandre, Benjamin Daumas‐Duport, Hubert Desal, Lili Detraz, Cécile Preterre, Valérie Wolff, Raoul Pop, Yannick Bejot, Frédéric Ricolfi, Laura Baptiste, Pierre‐Olivier Comby, Brivael Lemogne, Pierre Thouant, Jean‐Christophe Gentric, Serge Timsit, François‐Mathias Merrien, Lorena Nico, Julien Ognard, Laurina Simoni, Chrysanthi Papagiannaki, Ozlem Ozkul, Aude Triquenot Bagan, Michel Piotin, Michael Obadia, Pierre Seners, Nasreddine Nouri, Hilde Henon, Marie Bodenant, Nicolas Bricout, Barbara Casolla, Nelly Dequatre, Lucie Della Shiava, Maco Pasi, François Caparros, Laurent Puy, Arnaud Karam, Olfa Kaaouana, Kaelig Watel, Giuseppe Scopelliti, Mariam Annan, Grégoire Boulouis, Richard Bibi, Arnaud Bretonniere, Marie Gaudron, Denis Herbreteau, Héloise Ifergan, Kevin Jannot, Elisabeth Molinier, Maco Pasi, Cyril Chivot, Chantal Lamy, Emmanuel Wiener, Audrey Arnoux Courselle, Sandrine Canaple, Elisa Ouin, Charbel Mounayer, Francisco Macian Montoro, Suzana Saleme, Omer Eker, Tae‐Hee Cho, Morgane Laubacher, Roberto Riva, Christophe Cognard, Jean‐François Albucher, Lionel Calviere, Louis Fontaine, Jean‐Marc Olivot, Nicolas Raposo, Alain Viguier, Laurent Suissa, Hervé Brunel, Emilie Doche, Nadia Laksiri, Stephanie Machado, Ophelie Osman, Roxane Peres, Emanuelle Robinet, Caroline Rey, Federico Di Maria, Bertrand Lapergue, Emmanuel Chabert, Anna Ferrier, Elie Lteif, Pere Cardona, Lara Blanca, Helena Quesada, Ana Núñez, Andrés Paipa, Mònica Millán, Alejandro Bustamante, Laura Dorado Bouix, Christopher Calib, Jaime Carbonell, Gema Eugenia García Amor, Garbiñe Ezcurra, Belén Flores, Manuel Gómez Choco, Meritxell Gomis Cortina, María Hernández Pérez, Marina Hernández, Clara Larrañaga, Manuel Domínguez Lizarbe, Marina Martínez, Alex Menéndez Albarracín, Natalia Pérez de la Ossa, Neus Rabaneda, Anna Ramos Pachón, Luis Alejandro Rodríguez, Sara Rubio, Isabel Puig, Daniel Santana l, Adrian Valls, Barbara Yugueros, Denisse Wenger, Arturo Renú, Sergio Amaro, Mircea Balasa, Jose Maria Cabrera, Ángel Chamorro, Estefania Conde, Jose Miguel Contador, Antonio Doncel‐Mariano, Mar Guasp, Laura Llansó, Laura Llull, Gerard Mayà Casalprim, Carmen Montejo, Alejandro Rodríguez, Salvatore Rudilosso, Almudena Sánchez, Daniel Santana, Xabier Urra Nuin, Víctor Augusto Vera Monge, Juan F. Arenillas, Mercedes De Lera, María Esther Ramos, María del Mar Freijo, Garazi Aguirre, Laura Cabral, Irene Díaz, Alejandro Durán Lozano, Alain Luna, Jon Martín, Ana Moreno Estébanez, Walter Sifontes, Iratxe Ugarriza, Elena López‐Cancio, Pedro Vega, Lorena Benavente, Sergio Calleja Puerta, María Castañón Apilánez, Álvaro Criado, David Fuentes, Carmen García‐Cabo, Montserrat González Delgado, Gemma María González, Javier Molina Gil, Davinia Larrosa Campo, Begoña López López, Antía Reguera Acuña, María Rico Santos, Patricia Zunzunegui +258 morewiley +1 more sourceGenetic and Population Analyses Implicate Thyroid‐Related Regulation of RNF144B in Chondrocalcinosis
Arthritis &Rheumatology, EarlyView.Objective
Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5% to 15% of the general population and has recently been identified as an osteoarthritis risk factor. However, its biologic pathways remain unclear.Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H. G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce B. J. van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer +15 morewiley +1 more source
