Results 171 to 180 of about 7,181,199 (327)

A Skewed Loss Function for Correcting Predictive Bias in Brain Age Prediction. [PDF]

IEEE Trans Med Imaging, 2023
Wang H, Treder MS, Marshall D, Jones DK, Li Y.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Automated Alzheimer's disease detection using active learning model with reinforcement learning and scope loss function. [PDF]

Npj Ment Health Res
He Z, Govindarajan V, Yang J, Abdel-Salam M, Shaikh ZA, Por LY, Alizadehsani R, Tan RS, Rajendra Acharya U.   +8 more
europepmc   +1 more source

Loss function of NtGA3ox1 delays flowering through impairing gibberellins metabolite synthesis in Nicotiana tabacum. [PDF]

Front Plant Sci, 2023
Deng L, Li C, Gao Q, Yang W, Jiang J, Xing J, Xiang H, Zhao J, Yang Y, Leng P.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A context aware multiclass loss function for semantic segmentation with a focus on intricate areas and class imbalances. [PDF]

Sci Rep
Ghanaei Z, Rouhani M.
europepmc   +1 more source

Application of FGD-BCEL loss function in segmenting temporal lobes on localized CT images for radiotherapy. [PDF]

Front Oncol, 2023
Wen X, Liang B, Zhao B, Hu X, Yuan M, Hu W, Liu T, Yang Y, Xing D.   +8 more
europepmc   +1 more source

Heterozygous loss-of-function mutation in Odd-skipped related 1 (Osr1) is associated with vesicoureteric reflux, duplex systems, and hydronephrosis [PDF]

, 2017
Marie-Lyne Fillion, Jasmine El Andalousi, Fatima Tokhmafshan, Vasikar Murugapoopathy, Christine L. Watt, Inga J. Murawski, John-Paul Capolicchio, Mohamed Abou El‐Ghar, Roman Jednak, Indra R. Gupta   +9 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion. [PDF]

Front Med (Lausanne)
Wang S, Wu T, Huang W, Du J, Chen Z, Xiao Z, Gao Q, Liu Y, Chen Y, Guo P, Zeng N, Liao J, Yang Y, Zheng J, Chen H, Liu Y, Lv F.   +16 more
europepmc   +1 more source