Results 201 to 210 of about 7,181,199 (327)

Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa

, 2014
Adeseye Adekeye, Mohammad Haeri, Eduardo Solessio, Barry E. Knox   +3 more
openalex   +2 more sources

Loss-of-Function Mutations in LRRC6 , a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms, Cause Primary Ciliary Dyskinesia [PDF]

, 2012
Esther Kott, Philippe Duquesnoy, Bruno Copin, Marie Legendre, Florence Dastot‐Le Moal, Guy Montantin, Ludovic Jeanson, Aline Tamalet, Jean‐François Papon, Jean‐Pierre Siffroi, Nathalie Rives, Valérie Mitchell, Jacques de Blic, A. Coste, Annick Clément, Denise Escalier, Aminata Touré, Estelle Escudier, Serge Amselem   +18 more
openalex   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

[A coronary artery plaque segmentation method based on focal weighted accuracy loss function]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Xiong F, Lu H, Li L, Jiang R.
europepmc   +1 more source

Research of segmentation recognition of small disease spots on apple leaves based on hybrid loss function and CBAM. [PDF]

Front Plant Sci, 2023
Zhang X, Li D, Liu X, Sun T, Lin X, Ren Z.   +5 more
europepmc   +1 more source

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

, 2014
Yajuan Wang, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yan V. Sun, Robert C. Elston, Scott M. Williams, Stephen S. Rich, Ting‐Wei Mu, Xiaofeng Zhu   +13 more
openalex   +2 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism. [PDF]

Elife
Wu W, Yu M, Li Q, Zhao Y, Zhang L, Sun Y, Wang Z, Gong Y, Wang W, Liu C, Zhang J, Tang Y, Xu X, Guo X, Zhan J, Zhang H.   +15 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

CAML-PSPNet: A Medical Image Segmentation Network Based on Coordinate Attention and a Mixed Loss Function. [PDF]

Sensors (Basel)
Li Y, Li P, Wang H, Gong X, Fang Z.
europepmc   +1 more source