Results 81 to 90 of about 393,254 (286)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

PAC-Bayesian Theory Meets Bayesian Inference [PDF]

, 2016
We exhibit a strong link between frequentist PAC-Bayesian risk bounds and the Bayesian marginal likelihood. That is, for the negative log-likelihood loss function, we show that the minimization of PAC-Bayesian generalization risk bounds maximizes the ...
Bach, Francis, Germain, Pascal, Lacoste, Alexandre, Lacoste-Julien, Simon   +3 more
core   +3 more sources

Sequential minimal optimization for SVM with pinball loss [PDF]

Neurocomputing, 2015
To pursue the insensitivity to feature noise and the stability to re-sampling, a new type of support vector machine (SVM) has been established via replacing the hinge loss in the classical SVM by the pinball loss and was hence called a pin-SVM. Though a different loss function is used, pin-SVM has a similar structure as the classical SVM. Specifically,
Huang, Xiaolin, Shi, Lei, Suykens, Johan
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Survey of Machine Learning Techniques for Optimal Capacitor Placement and Sizing in Smart Distribution Networks

IEEE Access
The increasing complexity of modern power distribution networks necessitates advanced strategies for reactive power compensation, particularly in capacitor placement and sizing.
Kwabena Addo, Katleho Moloi, Musasa Kabeya, Evans Eshiemogie Ojo   +3 more
doaj   +1 more source

Load Concentration Factor Based Analytical Method for Optimal Placement of Multiple Distribution Generators for Loss Minimization and Voltage Profile Improvement

Energies, 2016
This paper presents novel separate methods for finding optimal locations, sizes of multiple distributed generators (DGs) simultaneously and operational power factor in order to minimize power loss and improve the voltage profile in the distribution ...
Mohsin Shahzad, Ishtiaq Ahmad, Wolfgang Gawlik, Peter Palensky   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Minimization of Transmission Line Losses Through System Topology Reconfiguration

Energies
This research proposes a methodology for minimizing losses in transmission lines (TLs), considering the reconfiguration of the architecture of the electrical power system (EPS). The implementation of this methodology redirects the power flow with optimal
David Orbea, Diego Carrión, Manuel Jaramillo   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Loss Minimization-Based Sensorless Control of High-Speed Induction Motor Considering Core Loss

IEEE Access
This paper presents loss-minimizing sensorless control (LMC) strategies utilized to optimize the energy of high-speed induction motor (HSIM) drives. A machine’s ability to operate effectively depends on the estimation of its electrical losses ...
Tadele Ayana, Piotr Kolodziejek, Marcin Morawiec, Lelisa Wogi   +3 more
doaj   +1 more source