Results 111 to 120 of about 4,990,585 (300)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Cross‐entropy method for distribution power systems reconfiguration
Engineering Reports, 2019 Cross‐entropy (CE) is a powerful simulation method for the solution of continuous and combinatory optimization problems. The work presented here utilizes the CE method for the optimal topology of distribution power systems (DPSs).
Karim Sebaa, Ayetül Gelen, Hassan Nouri
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Testing for loss severity: Impact on loss reduction
Risk Management and Insurance ReviewAbstract This paper examines moral hazard in insurance when individuals are faced with different loss reduction functions and able to test for loss severity with results potentially being observed by insurers. It is important to distinguish between the types of loss reduction, that is, monetary or physical effort‐based, and the ...
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
CT dose reduction factors in the thousands using X-ray phase contrast
, 2017 Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order of magnitude or more compared to conventional radiographs.
. +8 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
ACTIVE POWER LOSS REDUCTION BY SYNTHESIZED ALGORITHM
International Journal of Research -GRANTHAALAYAH, 2018 In this paper, Synthesized Algorithm (SA) proposed to solve the optimal reactive power problem. Proposed Synthesized Algorithm (SA) is a combination of three well known evolutionary algorithms, namely Differential Evolution (DE) algorithm, Particle Swarm Optimization (PSO) algorithm, and Harmony Search (HS) algorithm. It merges the general operators of
openaire +2 more sources