Results 141 to 150 of about 6,916 (310)

Renal oncocytomatosis: A rare case of bilateral multifocal oncocytomas 15 Years after solitary lesion: a case report. [PDF]

Urol Case Rep
Rosario M, Sitharthan D, Sved P.
europepmc   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Spontaneous Coronary Artery Dissection: Menopausal Symptoms and Hormone Therapy Use in 661 Women. [PDF]

JACC Adv
Battenberg AE, Hayes SN, Kok SN, Faubion SS, Tweet MS.   +4 more
europepmc   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Local excision in rectal cancer: When and for whom? [PDF]

World J Gastrointest Oncol
Demirli Atici S, Canda AE, Terzi MC.
europepmc   +1 more source

Effect of reserve protection level and governance on tree cover loss and gain [PDF]

Natasha Stoudmann, Jason Byrne, Vanessa M. Adams   +2 more
openalex   +1 more source

Loss reserving with kernel functions

, 2017
Loss reserving is a fundamental concept of actuarial mathematics. A traditionally used method is the chain ladder method. While it is a simple and robust method and works well in many cases, it also has its limitations. The chain ladder method is applied to aggregated data triangle, in a way similar to constructing histograms.
openaire   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Acute hepatitis of unknown origin in 38-year-old man: A case report. [PDF]

Medicine (Baltimore)
Trifonov P, Todovichin D, Marinova C, Zasheva A, Komitov D, Nikolov R, Mihaylova-Garnizova R.   +6 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source