Results 41 to 50 of about 70,772 (294)

Bootstrapping vs. Asymptotic Theory in Property and Casualty Loss Reserving [PDF]

open access: yes, 2015
One of the key functions of a property and casualty (P&C) insurance company is loss reserving, which calculates how much money the company should retain in order to pay out future claims.
DiFronzo, Andrew J., Jr.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

A Bayesian copula model for stochastic claims reserving [PDF]

open access: yes
We present a full Bayesian model for assessing the reserve requirement of multiline Non-Life insurance companies. Bayesian models for claims reserving allow to account for expert knowledge in the evaluation of Outstanding Loss Liabilities, allowing the ...
Luca Regis
core   +3 more sources

Design and Realization of High-density FDR Interconnection Switch Board [PDF]

open access: yesJisuanji gongcheng, 2016
Aiming at the deficiency of signal integrity for the Printed Circuit Board(PCB) design of high-density Fourteen Data Rate(FDR) interconnection switch,this paper proposes a solution scheme in the aspects of material selection,stackup assignment,wiring and
LIU Lu,CAO Yuesheng,DUO Ruihua
doaj   +1 more source

Linear Stochastic Reserving Methods [PDF]

open access: yes, 2017
In this article we want to motivate and analyse a wide family of reserving models, called linear stochastic reserving methods (LSRMs). The main idea behind them is the assumption that the (conditionally) expected changes of claim properties during a ...
Dahms, René
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Generalized Log-Normal Chain-Ladder

open access: yes, 2018
We propose an asymptotic theory for distribution forecasting from the log normal chain-ladder model. The theory overcomes the difficulty of convoluting log normal variables and takes estimation error into account. The results differ from that of the over-
B. Nielsen   +6 more
core   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu   +5 more
wiley   +1 more source

The Linear Markov Property in Credibility Theory [PDF]

open access: yes, 2017
We study the linear Markov property, i.e. the possibility of basing the credibility estimator on data of the most recent time period without loss of accuracy. Necessary and sufficient conditions are derived generally.
Witting, Thomas
core  

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