Results 121 to 130 of about 3,103,671 (306)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Theoretical Investigation of Pressure Distribution in a Multi-Typal Transport Unit
Acta Technologica Agriculturae, 2018 This article presents the results from the theoretical research of tension loading in a channel of fixing conveyor of the apparatus for flax beating and scutching.
Nalobina Olena +4 more
doaj +1 more source
Weighted Proportional Losses Solution [PDF]
We propose and characterize a new solution for problems with asymmetric bargaining power among the agents that we named weighted proportional losses solution.
Jaume García Segarra +1 more
core
Filtenna Integration Achieving Ideal Chebyshev Return Losses [PDF]
, 2014 This paper demonstrates that it is possible to find an ideal filter response (Chebyshew, Butterworth,..) considering the antenna as the last resonator of a filter under certain circumstances related with the antenna performance and the bandwidth of the ...
Collado, C. +5 more
core +1 more source
Systematic measurement of the intrinsic losses in various kinds of bulk fused silica
, 2004 We systematically measured and compared the mechanical losses of various kinds of bulk fused silica. Their quality factors ranged widely from 7x10^5 to 4x10^7, the latter being one of the highest reported among bulk fused silica.
Abramovici +34 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Scaling laws for precision in quantum interferometry and bifurcation landscape of optimal state
, 2010 Phase precision in optimal 2-channel quantum interferometry is studied in the limit of large photon number $N\gg 1$, for losses occurring in either one or both channels. For losses in one channel an optimal state undergoes an intriguing sequence of local
Durkin, Gabriel A. +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source