Results 171 to 180 of about 1,306,254 (312)
Containing outbreaks at their source: an illustrative example of partial economic returns to US global health security funding. [PDF]
J Glob HealthKostova D +5 more
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Estimating the Economic Impact of Neonatal Calf Diarrhea Agents With Decision Tree Analysis and the Monte Carlo Simulation Model. [PDF]
Vet Med SciKüçükoflaz M +7 more
europepmc +1 more source
Loss of Use, Loss of Ability argues that human abilities do not persist by default but only within the developmental environments that train and demand them. When a practice ceases to be used at scale, the underlying capacity decays, and the form of living that depends on it collapses.
openaire +2 more sources
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Earnings Management to Avoid Losses: a cost of debt explanation [PDF]
In this paper we analyze firms’ earnings management behavior to avoid losses conditional on the (asymmetric) incentive underlying market (positive/negative) returns.
Peter F. Pope, José A. C. Moreira
core
When Losses Matter More: A Dynamic Reference-Dependent Evaluation of Suicide Risk. [PDF]
Risk AnalParhi M +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Effects of intrinsic capacity on health-related outcomes are moderated by frailty status among community-dwelling older adults. [PDF]
J Nutr Health AgingZhou K, Ng YS, Tay EL, Mah SM, Tay L.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source