Results 221 to 230 of about 3,625,133 (352)

Impact of drought on global food security by 2050. [PDF]

Nat Commun
Kraklow VA, Paff K, Comeau D, Solander K, Pitts TR, Price SF, Xu C.   +6 more
europepmc   +1 more source

Introduction to Volume Eight: Wins and Losses [PDF]

, 2017
Brada-Williams, Noelle
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

"Vulnerabilities and compound risks of escalating climate disasters in the Brazilian Amazon". [PDF]

Nat Commun
Pinho PF, Silvestrini R, Fellows M, Perez L, Alencar A, Guyot C, Moutinho P, Lapola D, Stringer L.   +8 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evolution of the Metazoan Protein Domain Repertoire Revealed by a Birth-Death-Gain Model. [PDF]

J Mol Evol
Xiao Y, Stolzer M, Wasserman L, Durand D.   +3 more
europepmc   +1 more source

In vivo corneal confocal microscopy detects progressive loss of epithelial cells and sub-basal nerve fibers over 2 years in young patients with type 1 diabetes

, 2017
Eszter Deák, Eszter Szalai, Noémi Tóth, András Berta, Rayaz A. Malik, Adrienne Csutak   +5 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Economic shocks and mental health in Bangladesh. [PDF]

BMJ Glob Health
Alam SA, Raza WA, Pörtner CC, Wahid SS, Sarker M.   +4 more
europepmc   +1 more source

My loss [PDF]

British Journal of General Practice, 2019
openaire   +2 more sources