Results 51 to 60 of about 115,368,257 (249)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Lost in (Cyber-)Space?

, 2013
Lost in (Cyber-)Space? Das Stadtarchiv Amberg in der schönen neuen Welt des Web 2.0 So lautete der Titel des heutigen Kurzvortrags von Jörg Fischer auf dem Deutschen Archivtag (Fachgruppensitzung 2, Kommunale Archive). Man hätte den Vortrag mal aufnehmen
Joachim Kemper
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Tobacco, heated tobacco products, e-cigarette, alcohol, cannabis and other psychotropic substances. Polysubstance use during the COVID-19 pandemic in Italy [PDF]

Objective. Psychoactive substance use is largely found to involve multiple substances. In recent years, the COVID-19 pandemic has changed psychoactive substance use patterns. Aim of this study is to investigate profiles of polysubstance and their pattern
Mortali, Claudia, Stival, Chiara, Alessandra Lugo, the “LOST IN ITALY” and “LOST IN TOSCANA” Study Investigators, Cerrai, Sonia, Mastrobattista, Luisa, Cosimo Campagni, “LOST IN ITALY” and “LOST IN TOSCANA” Study Investigators, Carreras, Giulia, Chiara Stival, Silvano Gallus, Giulia Carreras, Gallus, Silvano, Sonia Cerrai, Odone, Anna, Luisa Mastrobattista, Claudia Mortali, Gorini, Giuseppe, Amerio, Andrea, Campagni, Cosimo, Lugo, Alessandra, Giuseppe Gorini, Andrea Amerio, Anna Odone   +23 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

LOST in Space: Optimal Triangulation for Celestial Localization

, 2022
Presented at the 3rd Space Imaging Workshop in Atlanta, GA.Optical measurements are a key part of modern interplanetary navigation. The statistically optimal Linear Optimal Sine Triangulation (LOST) algorithm is applied to the context of celestial ...
Henry, Sébastien, Christian, John A.
core  

Permanent-magnet quadrupoles for an interdigital H-mode drift tube linear accelerator: Optimization code and adjustable magnet design

Physical Review Accelerators and Beams, 2018
Magnets to be used for the internal quadrupoles of an interdigital H-mode drift tube linear accelerator (IH-DTL) using KONUS beam dynamics should be both compact in size and high in focusing field gradient.
Matthew J. Easton, Haipeng Li (李海鹏), Yuanrong Lu (陆元荣), Jie Zhu (朱杰), Pierre-Daniel Pfister   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

What am I doing here? Making sense of why I am drawing in an empty care home residents’ lounge

Cogent Gerontology
As an integral part of my practice-led PhD research into how drawing can help us to understand loss in the elderly, the ill and the dying, I make reportage drawings in residential care homes. This account focusses on a private care home, where I draw, in
Ellen Bell
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source