Results 81 to 90 of about 89,974 (258)

Development and Performance Evaluation of a Gel-Based Plugging System for Complex Fractured Formations Using Acrylic Resin Particles

Gels
The issue of fluid loss in fractured formations presents a significant challenge in petroleum engineering, often leading to increased operational costs and construction risks. To address the limitations of traditional lost circulation materials (LCMs) in
Lei Yao, Xiaohu Quan, Jihe Ma, Ge Wang, Qi Feng, Hui Jin, Jun Yang   +6 more
doaj   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Experimental investigation of deformable additives as loss circulation control agent during drilling and well construction

Scientific Reports
Lost circulation is known as one of the most important challenges during drilling. In addition to high costs due to mud loss and nonproductive time, lost circulation may lead to several consequences, including stuck pipes, wellbore collapse, poor hole ...
Rasoul Nazemi, Ghasem Zargar, Vahid Nooripoor   +2 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Lost circulation in fractured carbonate formations: Mechanisms, treatment strategies and field evidence from Kurdistan Region of Iraq

Journal of Engineering and Applied Science
Lost circulation is a recurring and costly challenge in drilling operations, causing severe wellbore instability, non-productive time (NPT), and increased drilling costs.
Jagar A. Ali, Awar Khalid, Arya Issa, Mardin Abdalqadir   +3 more
doaj   +1 more source

Research Progress of Supramolecular Gels in the Field of Petroleum Engineering

Gels
Traditional petroleum engineering materials have problems such as single functionality and poor environmental adaptability in terms of lost circulation control and enhanced oil recovery.
Liyao Dai, Jinsheng Sun, Kaihe Lv, Yingrui Bai, Jianlong Wang, Chaozheng Liu, Mei-Chun Li   +6 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Research progress and development of deep and ultra-deep drilling fluid technology

Petroleum Exploration and Development
The research progress of deep and ultra-deep drilling fluid technology systematically reviewed, the key problems existing are analyzed, and the future development direction is proposed.
Jinsheng SUN, Jingbin YANG, Yingrui BAI, Kaihe LYU, Fengbao LIU   +4 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Preparation of Composite Nano-Silica and Polymer Gel and Its Function as Lost Circulation Material

Zuanjingye yu wanjingye
Gel lost circulation materials (LCMs) presently in use have several shortcomings such as low strength, poor toughness and uncontrollable gelling time etc. A high gel strength composite nanomaterial and polymer gel LCM has been developed to overcome these
Wenshuang YAO, Po LIU, Huijun HAO, Yan YE, Rongchao CHENG, Fan LIU, Hanxuan SONG   +6 more
doaj   +1 more source