Results 81 to 90 of about 493,362 (305)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Lot sizing and scheduling: Industrial extensions and research opportunities
, 2011 The editorial section of International Journal of Production Research provides information about industrial extensions and research opportunities in the fields of lot sizing and scheduling in industries. Some of the papers published in the journal reveal
Bernardo Almada-Lobo +5 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
, 2011 Several mixed integer programming formulations have been proposed for modeling capacitated multi-level lot sizing problems with setup times. These formulations include the so-called facility location formulation, the shortest route formulation, and the ...
Akartunali, Kerem +7 more
core +1 more source
In this paper we introduce a new class of OR games: economic lot-sizing (ELS) games.There are a number of retailers that have a known demand for a fixed number of periods.To satisfy demand the retailers order products at the same manufacturer. By placing
Borm, P.E.M. +2 more
core +2 more sources
Mathematical Programming for Lot Sizing and Production Scheduling in Foundries
Archives of Foundry Engineering, 2014 The problem considered in the paper is motivated by production planning in a foundry equipped with the furnace and casting line, which provides a variety of castings in various grades of cast iron/steel for a large number of customers.
Duda J., Stawowy A., Basiura R.
doaj +1 more source
Note—Lot-Sizing and Sequencing Delays [PDF]
Management Science, 1987 In production scheduling, time performance is usually taken to be the province of sequencing models which take task processing times to be given. However, in practice, processing times can often be controlled by the choice of lot sizes which thus have a major impact on makespan, waiting times, flow times and other measures.
openaire +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source