Results 31 to 40 of about 87,919 (217)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Cyber Physical Systems: A New Approach to Power Electronics Simulation, Control and Testing

Advances in Electrical and Computer Engineering, 2012
This paper presents a Cyber Physical Systems approach to power electronics simulation, control and testing. We present a new framework based on generalized hybrid automaton and application specific ultra-low latency high-speed processor architecture ...
CELANOVIC, N. L., CELANOVIC, I. L., IVANOVIC, Z. R.   +2 more
doaj   +1 more source

Modeling a Pluse-Width Modulation(PWM) Rectifier in 3D Space [PDF]

E3S Web of Conferences
Power electronics pertains to a category of devices that convert electrical power from one form to another. Semiconductor devices act as switches in power electronics circuits, serving as the central components responsible for voltage regulation.
Prasad Reddy M. Ram, Deepak Karanam, Pagidala Shiva Shankar, Pikkili Bhuvanesh, Rayaveera Nitin Narasimha, Shaik Moin Basheer   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical Simulation and Experimental Research of the Hot-Wire Method for Thermal Insulation Materials

Buildings
The thermal conductivity of thermal insulation materials is a critical parameter for assessing energy efficiency and performance in building, industrial, and aerospace applications.
Jiaxuan Che, Yaxin Zhang, Junbang Yao, Xiaojing Li, Xing Liu, Boxiang Liu, Tao Yang   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

ISCAD — Design, control and car integration of a 48 volt high performance drive

CES Transactions on Electrical Machines and Systems, 2019
Through its new technology the ISCAD system provides up to 300 kW with a safe-to-touch 48 Volt battery. This results in a high-performance drive that is intrinsically electrically safe. The novel machine design requires new concepts for power electronics,
S. Runde, A. Baumgardt, O. Moros, B. Rubey, D. Gerling   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Innovative Pressure Sensor Platform and Its Integration with an End-User Application

Sensors, 2014
This paper describes the fully integration of an innovative and low-cost pressure sensor sheet based on a bendable and printed electronics technology. All integration stages are covered, from most low-level functional system, like physical analog sensor ...
Antonio Flores-Caballero, Dorin Copaci, María Dolores Blanco, Luis Moreno, Jaime Herrán, Iván Fernández, Estíbaliz Ochoteco, German Cabañero, Hans Grande   +8 more
doaj   +1 more source